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Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant

Lymphoplasmacyte-rich meningioma (LRM) is a rare histologic subtype of meningioma. Creeping-growth pattern is uncommon in meningioma, and the mechanism is unclear. Here, we report a 44-year-old man presented with extremities weakness for 2 months and incontinence for 2 weeks. Head and neck MRI revea...

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Autores principales: Li, Jiuhong, Zan, Xin, Feng, Min, Deng, Xueyun, Zhang, Si, Liu, Wenke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712332/
https://www.ncbi.nlm.nih.gov/pubmed/34970592
http://dx.doi.org/10.3389/fsurg.2021.775560
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author Li, Jiuhong
Zan, Xin
Feng, Min
Deng, Xueyun
Zhang, Si
Liu, Wenke
author_facet Li, Jiuhong
Zan, Xin
Feng, Min
Deng, Xueyun
Zhang, Si
Liu, Wenke
author_sort Li, Jiuhong
collection PubMed
description Lymphoplasmacyte-rich meningioma (LRM) is a rare histologic subtype of meningioma. Creeping-growth pattern is uncommon in meningioma, and the mechanism is unclear. Here, we report a 44-year-old man presented with extremities weakness for 2 months and incontinence for 2 weeks. Head and neck MRI revealed diffuse creeping-growth nodular meningeal masses with skull base, tentorium, sella area, and C1-6 vertebral plane involvement. An operation was carried out, cervical and lower clivus part of the lesion was resected, but gross total resection could not be achieved due to the widespread lesions. Pathologic examination revealed the diagnosis of LRM. The patient is free from progression clinically 3 months postoperatively. We also conducted a systematic literature review about LRM with creeping-growth pattern. A total of only nine cases (including the present case) of creeping-growth LRMs were included and analyzed in terms of clinical manifestations, radiological features, treatment, and outcome. LRMs show a higher rate (7.5%) of creeping-growth pattern than other types of meningiomas. The average creeping length of all creeping-growth LRMs was 11.4 ± 10.9 cm (range, 3–30 cm). Most cases (66.7%) had obvious peritumoral edema. Total removal rate is low (33.3%), and two of them (22.2%) received biopsy, followed by steroids treatment (or further immunosuppressive drugs therapy) and radiotherapy. The recurrence rate is higher than conventional LRMs (22.2 vs. 11.3%), and one patient (11.1%) died 11 months after treatment. Creeping-growth pattern in LRM may be considered as a general radiologic variant. The recurrence rate is higher compared with LRM with round/swelling pattern. We speculated that the pathogenesis of creeping growth in LRM may be associated with damage of lymphatic systems of the central nervous system.
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spelling pubmed-87123322021-12-29 Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant Li, Jiuhong Zan, Xin Feng, Min Deng, Xueyun Zhang, Si Liu, Wenke Front Surg Surgery Lymphoplasmacyte-rich meningioma (LRM) is a rare histologic subtype of meningioma. Creeping-growth pattern is uncommon in meningioma, and the mechanism is unclear. Here, we report a 44-year-old man presented with extremities weakness for 2 months and incontinence for 2 weeks. Head and neck MRI revealed diffuse creeping-growth nodular meningeal masses with skull base, tentorium, sella area, and C1-6 vertebral plane involvement. An operation was carried out, cervical and lower clivus part of the lesion was resected, but gross total resection could not be achieved due to the widespread lesions. Pathologic examination revealed the diagnosis of LRM. The patient is free from progression clinically 3 months postoperatively. We also conducted a systematic literature review about LRM with creeping-growth pattern. A total of only nine cases (including the present case) of creeping-growth LRMs were included and analyzed in terms of clinical manifestations, radiological features, treatment, and outcome. LRMs show a higher rate (7.5%) of creeping-growth pattern than other types of meningiomas. The average creeping length of all creeping-growth LRMs was 11.4 ± 10.9 cm (range, 3–30 cm). Most cases (66.7%) had obvious peritumoral edema. Total removal rate is low (33.3%), and two of them (22.2%) received biopsy, followed by steroids treatment (or further immunosuppressive drugs therapy) and radiotherapy. The recurrence rate is higher than conventional LRMs (22.2 vs. 11.3%), and one patient (11.1%) died 11 months after treatment. Creeping-growth pattern in LRM may be considered as a general radiologic variant. The recurrence rate is higher compared with LRM with round/swelling pattern. We speculated that the pathogenesis of creeping growth in LRM may be associated with damage of lymphatic systems of the central nervous system. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712332/ /pubmed/34970592 http://dx.doi.org/10.3389/fsurg.2021.775560 Text en Copyright © 2021 Li, Zan, Feng, Deng, Zhang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Li, Jiuhong
Zan, Xin
Feng, Min
Deng, Xueyun
Zhang, Si
Liu, Wenke
Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title_full Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title_fullStr Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title_full_unstemmed Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title_short Case Report: Creeping Growth in Lymphoplasmacyte-Rich Meningioma—A Radiologic Variant
title_sort case report: creeping growth in lymphoplasmacyte-rich meningioma—a radiologic variant
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712332/
https://www.ncbi.nlm.nih.gov/pubmed/34970592
http://dx.doi.org/10.3389/fsurg.2021.775560
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