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Selective G protein signaling driven by Substance P-Neurokinin Receptor dynamics

The neuropeptide Substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via G(q) and G(s) proteins. Neurokinin A also activates NK1R, but leads to selective G(q) signaling. How two stimuli yield distinct G protein signaling at the same G prote...

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Detalles Bibliográficos
Autores principales:	Harris, Julian A., Faust, Bryan, Gondin, Arisbel B., Dämgen, Marc André, Suomivuori, Carl-Mikael, Veldhuis, Nicholas A., Cheng, Yifan, Dror, Ron O., Thal, David M., Manglik, Aashish
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712391/ https://www.ncbi.nlm.nih.gov/pubmed/34711980 http://dx.doi.org/10.1038/s41589-021-00890-8

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