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Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disord...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712474/ https://www.ncbi.nlm.nih.gov/pubmed/34970175 http://dx.doi.org/10.3389/fpsyt.2021.803208 |
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author | Grunze, Heinz Csehi, Réka Born, Christoph Barabássy, Ágota |
author_facet | Grunze, Heinz Csehi, Réka Born, Christoph Barabássy, Ágota |
author_sort | Grunze, Heinz |
collection | PubMed |
description | The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disorders, which is also expressed by the high rate of comorbidity. Although partial dopamine agonists/antagonists acting on D(2) and D(3) receptors have an established role in treating BD, their usefulness in SUD is less clear. However, dopamine D(3) receptors were shown to play a central role in SUD and BD, making D(2)/D(3) partial agonists/antagonists a potential target for both disorders. This narrative review examines whether these substances bear the promise of a future therapeutic approach especially in patients with comorbid BD and SUD. |
format | Online Article Text |
id | pubmed-8712474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87124742021-12-29 Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System Grunze, Heinz Csehi, Réka Born, Christoph Barabássy, Ágota Front Psychiatry Psychiatry The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disorders, which is also expressed by the high rate of comorbidity. Although partial dopamine agonists/antagonists acting on D(2) and D(3) receptors have an established role in treating BD, their usefulness in SUD is less clear. However, dopamine D(3) receptors were shown to play a central role in SUD and BD, making D(2)/D(3) partial agonists/antagonists a potential target for both disorders. This narrative review examines whether these substances bear the promise of a future therapeutic approach especially in patients with comorbid BD and SUD. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712474/ /pubmed/34970175 http://dx.doi.org/10.3389/fpsyt.2021.803208 Text en Copyright © 2021 Grunze, Csehi, Born and Barabássy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Grunze, Heinz Csehi, Réka Born, Christoph Barabássy, Ágota Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title | Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title_full | Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title_fullStr | Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title_full_unstemmed | Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title_short | Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System |
title_sort | reducing addiction in bipolar disorder via hacking the dopaminergic system |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712474/ https://www.ncbi.nlm.nih.gov/pubmed/34970175 http://dx.doi.org/10.3389/fpsyt.2021.803208 |
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