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Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System

The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disord...

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Autores principales: Grunze, Heinz, Csehi, Réka, Born, Christoph, Barabássy, Ágota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712474/
https://www.ncbi.nlm.nih.gov/pubmed/34970175
http://dx.doi.org/10.3389/fpsyt.2021.803208
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author Grunze, Heinz
Csehi, Réka
Born, Christoph
Barabássy, Ágota
author_facet Grunze, Heinz
Csehi, Réka
Born, Christoph
Barabássy, Ágota
author_sort Grunze, Heinz
collection PubMed
description The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disorders, which is also expressed by the high rate of comorbidity. Although partial dopamine agonists/antagonists acting on D(2) and D(3) receptors have an established role in treating BD, their usefulness in SUD is less clear. However, dopamine D(3) receptors were shown to play a central role in SUD and BD, making D(2)/D(3) partial agonists/antagonists a potential target for both disorders. This narrative review examines whether these substances bear the promise of a future therapeutic approach especially in patients with comorbid BD and SUD.
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spelling pubmed-87124742021-12-29 Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System Grunze, Heinz Csehi, Réka Born, Christoph Barabássy, Ágota Front Psychiatry Psychiatry The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression. Common genetic markers and underlying cellular processes, such as kindling, support the close link between these disorders, which is also expressed by the high rate of comorbidity. Although partial dopamine agonists/antagonists acting on D(2) and D(3) receptors have an established role in treating BD, their usefulness in SUD is less clear. However, dopamine D(3) receptors were shown to play a central role in SUD and BD, making D(2)/D(3) partial agonists/antagonists a potential target for both disorders. This narrative review examines whether these substances bear the promise of a future therapeutic approach especially in patients with comorbid BD and SUD. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712474/ /pubmed/34970175 http://dx.doi.org/10.3389/fpsyt.2021.803208 Text en Copyright © 2021 Grunze, Csehi, Born and Barabássy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Grunze, Heinz
Csehi, Réka
Born, Christoph
Barabássy, Ágota
Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title_full Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title_fullStr Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title_full_unstemmed Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title_short Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System
title_sort reducing addiction in bipolar disorder via hacking the dopaminergic system
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712474/
https://www.ncbi.nlm.nih.gov/pubmed/34970175
http://dx.doi.org/10.3389/fpsyt.2021.803208
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