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Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective
Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712556/ https://www.ncbi.nlm.nih.gov/pubmed/34970125 http://dx.doi.org/10.3389/fnsys.2021.733898 |
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author | Mundorf, Annakarina Peterburs, Jutta Ocklenburg, Sebastian |
author_facet | Mundorf, Annakarina Peterburs, Jutta Ocklenburg, Sebastian |
author_sort | Mundorf, Annakarina |
collection | PubMed |
description | Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental and psychiatric disorders have been associated with altered functional hemispheric asymmetries. However, findings concerning the relation between structural hemispheric asymmetries and disorders have largely been inconsistent, both within specific disorders as well as between disorders. In the present review, we compare structural asymmetries from a clinical neuroscience perspective across different disorders. We focus especially on recent large-scale neuroimaging studies, to concentrate on replicable effects. With the notable exception of major depressive disorder, all reviewed disorders were associated with distinct patterns of alterations in structural hemispheric asymmetries. While autism spectrum disorder was associated with altered structural hemispheric asymmetries in a broader range of brain areas, most other disorders were linked to more specific alterations in brain areas related to cognitive functions that have been associated with the symptomology of these disorders. The implications of these findings are highlighted in the context of transdiagnostic approaches to psychopathology. |
format | Online Article Text |
id | pubmed-8712556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87125562021-12-29 Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective Mundorf, Annakarina Peterburs, Jutta Ocklenburg, Sebastian Front Syst Neurosci Neuroscience Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental and psychiatric disorders have been associated with altered functional hemispheric asymmetries. However, findings concerning the relation between structural hemispheric asymmetries and disorders have largely been inconsistent, both within specific disorders as well as between disorders. In the present review, we compare structural asymmetries from a clinical neuroscience perspective across different disorders. We focus especially on recent large-scale neuroimaging studies, to concentrate on replicable effects. With the notable exception of major depressive disorder, all reviewed disorders were associated with distinct patterns of alterations in structural hemispheric asymmetries. While autism spectrum disorder was associated with altered structural hemispheric asymmetries in a broader range of brain areas, most other disorders were linked to more specific alterations in brain areas related to cognitive functions that have been associated with the symptomology of these disorders. The implications of these findings are highlighted in the context of transdiagnostic approaches to psychopathology. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712556/ /pubmed/34970125 http://dx.doi.org/10.3389/fnsys.2021.733898 Text en Copyright © 2021 Mundorf, Peterburs and Ocklenburg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Mundorf, Annakarina Peterburs, Jutta Ocklenburg, Sebastian Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title | Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title_full | Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title_fullStr | Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title_full_unstemmed | Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title_short | Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective |
title_sort | asymmetry in the central nervous system: a clinical neuroscience perspective |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712556/ https://www.ncbi.nlm.nih.gov/pubmed/34970125 http://dx.doi.org/10.3389/fnsys.2021.733898 |
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