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YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study

Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes contributed to neuroblastoma risk in previous studies. YTHDF2, a “reader” of RNA m6A modification, is involved in cancer progress...

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Autores principales: Zeng, Huijuan, Li, Meng, Liu, Jiabin, Zhu, Jinhong, Cheng, Jiwen, Li, Yong, Zhang, Jiao, Yang, Zhonghua, Li, Li, Zhou, Haixia, Li, Suhong, Xia, Huimin, Zou, Yan, He, Jing, Yang, Tianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712649/
https://www.ncbi.nlm.nih.gov/pubmed/34970571
http://dx.doi.org/10.3389/fmed.2021.797195
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author Zeng, Huijuan
Li, Meng
Liu, Jiabin
Zhu, Jinhong
Cheng, Jiwen
Li, Yong
Zhang, Jiao
Yang, Zhonghua
Li, Li
Zhou, Haixia
Li, Suhong
Xia, Huimin
Zou, Yan
He, Jing
Yang, Tianyou
author_facet Zeng, Huijuan
Li, Meng
Liu, Jiabin
Zhu, Jinhong
Cheng, Jiwen
Li, Yong
Zhang, Jiao
Yang, Zhonghua
Li, Li
Zhou, Haixia
Li, Suhong
Xia, Huimin
Zou, Yan
He, Jing
Yang, Tianyou
author_sort Zeng, Huijuan
collection PubMed
description Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes contributed to neuroblastoma risk in previous studies. YTHDF2, a “reader” of RNA m6A modification, is involved in cancer progression. Here, we estimated the association between a YTHDF2 gene rs3738067 A>G polymorphism and neuroblastoma susceptibility in 898 neuroblastoma patients and 1,734 healthy individuals from China. We found that the rs3738067 A>G could decrease neuroblastoma risk [AG vs. AA: adjusted odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.64–0.90, P = 0.002; AG/GG vs. AA: adjusted OR = 0.81, 95% CI = 0.69–0.95, P = 0.011). Besides, the rs3738067 AG/GG genotype was related to reduced neuroblastoma risk in the following subgroups: children aged 18 months and under, boys, patients with tumors originating from retroperitoneal, patients at clinical stage IV, and cases at clinical stages III plus IV. Importantly, false-positive report probability analysis proved our significant results worthy of close attention of. The expression quantitative trait locus analysis results revealed that the rs3738067 was associated with the expression of YTHDF2.
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spelling pubmed-87126492021-12-29 YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study Zeng, Huijuan Li, Meng Liu, Jiabin Zhu, Jinhong Cheng, Jiwen Li, Yong Zhang, Jiao Yang, Zhonghua Li, Li Zhou, Haixia Li, Suhong Xia, Huimin Zou, Yan He, Jing Yang, Tianyou Front Med (Lausanne) Medicine Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes contributed to neuroblastoma risk in previous studies. YTHDF2, a “reader” of RNA m6A modification, is involved in cancer progression. Here, we estimated the association between a YTHDF2 gene rs3738067 A>G polymorphism and neuroblastoma susceptibility in 898 neuroblastoma patients and 1,734 healthy individuals from China. We found that the rs3738067 A>G could decrease neuroblastoma risk [AG vs. AA: adjusted odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.64–0.90, P = 0.002; AG/GG vs. AA: adjusted OR = 0.81, 95% CI = 0.69–0.95, P = 0.011). Besides, the rs3738067 AG/GG genotype was related to reduced neuroblastoma risk in the following subgroups: children aged 18 months and under, boys, patients with tumors originating from retroperitoneal, patients at clinical stage IV, and cases at clinical stages III plus IV. Importantly, false-positive report probability analysis proved our significant results worthy of close attention of. The expression quantitative trait locus analysis results revealed that the rs3738067 was associated with the expression of YTHDF2. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712649/ /pubmed/34970571 http://dx.doi.org/10.3389/fmed.2021.797195 Text en Copyright © 2021 Zeng, Li, Liu, Zhu, Cheng, Li, Zhang, Yang, Li, Zhou, Li, Xia, Zou, He and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zeng, Huijuan
Li, Meng
Liu, Jiabin
Zhu, Jinhong
Cheng, Jiwen
Li, Yong
Zhang, Jiao
Yang, Zhonghua
Li, Li
Zhou, Haixia
Li, Suhong
Xia, Huimin
Zou, Yan
He, Jing
Yang, Tianyou
YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title_full YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title_fullStr YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title_full_unstemmed YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title_short YTHDF2 Gene rs3738067 A>G Polymorphism Decreases Neuroblastoma Risk in Chinese Children: Evidence From an Eight-Center Case-Control Study
title_sort ythdf2 gene rs3738067 a>g polymorphism decreases neuroblastoma risk in chinese children: evidence from an eight-center case-control study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712649/
https://www.ncbi.nlm.nih.gov/pubmed/34970571
http://dx.doi.org/10.3389/fmed.2021.797195
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