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Unveiling the Gating Mechanism of CRAC Channel: A Computational Study

CRAC channel is ubiquitous and its importance in the regulation of the immune system is testified by the severe immunodeficiencies caused by its mutations. In this work we took advantage of the availability of open and closed structures of this channel to run for the first time simulations of the wh...

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Detalles Bibliográficos
Autores principales: Guardiani, Carlo, Sun, Delia, Giacomello, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712694/
https://www.ncbi.nlm.nih.gov/pubmed/34970596
http://dx.doi.org/10.3389/fmolb.2021.773388