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Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target

AMG 966 is a bi-specific, heteroimmunoglobulin molecule that binds both tumor necrosis factor alpha (TNFα) and TNF-like ligand 1A (TL1A). In a first-in-human clinical study in healthy volunteers, AMG 966 elicited anti-drug antibodies (ADA) in 53 of 54 subjects (98.1%), despite a paucity of T cell ep...

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Detalles Bibliográficos
Autores principales:	Kroenke, Mark A., Barger, Troy E., Hu, Jenny, Miller, Mieke Jill, Kalenian, Kevin, He, Lidong, Hsu, Hailing, Bartley, Yessenia, Chow, Vincent Fung-Sing, Teixeira dos Santos, Marcia Cristina, Sullivan, Barbara A., Cheng, Laurence E., Parnes, Jane R., Padaki, Rupa, Kuhns, Scott, Mytych, Daniel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712722/ https://www.ncbi.nlm.nih.gov/pubmed/34970265 http://dx.doi.org/10.3389/fimmu.2021.782788

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