Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea

Gray mold caused by Botrytis cinerea is a devastating disease that leads to huge economic losses worldwide. Autophagy is an evolutionarily conserved process that maintains intracellular homeostasis through self-eating. In this study, we identified and characterized the biological function of the aut...

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Detalles Bibliográficos
Autores principales: Liu, Na, Zhou, Shanyue, Li, Baohua, Ren, Weichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712751/
https://www.ncbi.nlm.nih.gov/pubmed/34970250
http://dx.doi.org/10.3389/fmicb.2021.798363
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author Liu, Na
Zhou, Shanyue
Li, Baohua
Ren, Weichao
author_facet Liu, Na
Zhou, Shanyue
Li, Baohua
Ren, Weichao
author_sort Liu, Na
collection PubMed
description Gray mold caused by Botrytis cinerea is a devastating disease that leads to huge economic losses worldwide. Autophagy is an evolutionarily conserved process that maintains intracellular homeostasis through self-eating. In this study, we identified and characterized the biological function of the autophagy-related protein Atg6 in B. cinerea. Targeted deletion of the BcATG6 gene showed block of autophagy and several phenotypic defects in aspects of mycelial growth, conidiation, sclerotial formation and virulence. All of the phenotypic defects were restored by targeted gene complementation. Taken together, these results suggest that BcAtg6 plays important roles in the regulation of various cellular processes in B. cinerea.
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spelling pubmed-87127512021-12-29 Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea Liu, Na Zhou, Shanyue Li, Baohua Ren, Weichao Front Microbiol Microbiology Gray mold caused by Botrytis cinerea is a devastating disease that leads to huge economic losses worldwide. Autophagy is an evolutionarily conserved process that maintains intracellular homeostasis through self-eating. In this study, we identified and characterized the biological function of the autophagy-related protein Atg6 in B. cinerea. Targeted deletion of the BcATG6 gene showed block of autophagy and several phenotypic defects in aspects of mycelial growth, conidiation, sclerotial formation and virulence. All of the phenotypic defects were restored by targeted gene complementation. Taken together, these results suggest that BcAtg6 plays important roles in the regulation of various cellular processes in B. cinerea. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8712751/ /pubmed/34970250 http://dx.doi.org/10.3389/fmicb.2021.798363 Text en Copyright © 2021 Liu, Zhou, Li and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Liu, Na
Zhou, Shanyue
Li, Baohua
Ren, Weichao
Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title_full Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title_fullStr Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title_full_unstemmed Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title_short Involvement of the Autophagy Protein Atg6 in Development and Virulence in the Gray Mold Fungus Botrytis cinerea
title_sort involvement of the autophagy protein atg6 in development and virulence in the gray mold fungus botrytis cinerea
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712751/
https://www.ncbi.nlm.nih.gov/pubmed/34970250
http://dx.doi.org/10.3389/fmicb.2021.798363
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