Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents

Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H(2)O rapidly and efficiently afforded a library of novel 6-halo-2-phenyl-substituted 4-anilinoquinazolines. The methodology was compatible with numerous ortho-, meta-, and para-substituted N-methylanilines as well as substituted anilines...

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Detalles Bibliográficos
Autores principales: Nishimura, Rodolfo H V, dos Santos, Thiago, Murie, Valter E, Furtado, Luciana C, Costa-Lotufo, Leticia V, Clososki, Giuliano C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712970/
https://www.ncbi.nlm.nih.gov/pubmed/35003373
http://dx.doi.org/10.3762/bjoc.17.206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712970/
https://www.ncbi.nlm.nih.gov/pubmed/35003373
http://dx.doi.org/10.3762/bjoc.17.206

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