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Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community

The emergence of infections (and colonization) with Enterobacteriaceae-producing carbapenemases is a threatening public health problem. In the last decades, we watched an isolated case becoming a brutal outbreak, a sporadic description becoming an endemic problem. The present study aims to highlight...

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Autores principales: Gonçalves, Daniela, Cecílio, Pedro, Faustino, Alberta, Iglesias, Carmen, Branca, Fernando, Estrada, Alexandra, Ferreira, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713047/
https://www.ncbi.nlm.nih.gov/pubmed/34970236
http://dx.doi.org/10.3389/fmicb.2021.777054
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author Gonçalves, Daniela
Cecílio, Pedro
Faustino, Alberta
Iglesias, Carmen
Branca, Fernando
Estrada, Alexandra
Ferreira, Helena
author_facet Gonçalves, Daniela
Cecílio, Pedro
Faustino, Alberta
Iglesias, Carmen
Branca, Fernando
Estrada, Alexandra
Ferreira, Helena
author_sort Gonçalves, Daniela
collection PubMed
description The emergence of infections (and colonization) with Enterobacteriaceae-producing carbapenemases is a threatening public health problem. In the last decades, we watched an isolated case becoming a brutal outbreak, a sporadic description becoming an endemic problem. The present study aims to highlight the dissemination of IMP-22-producing Klebsiella pneumoniae in the North of Portugal, through the phenotypic and genotypic characterization of isolates collected from hospitalized patients (n=5) and out-patients of the emergency ward of the same acute care hospital (n=2), and isolates responsible for the intestinal colonization of residents in a Long-Term Care Facility (n=4). Pulsed-field gel electrophoresis (PFGE) results, associated with conjugation experiments pointed to a pattern of both vertical and horizontal dissemination. Overall, and complementing other studies that give relevance to IMP-22-producing K. pneumoniae in the clinical settings, here we show for the first time the public health threatening breach of the hospital frontier of this resistance threat, toward the community.
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spelling pubmed-87130472021-12-29 Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community Gonçalves, Daniela Cecílio, Pedro Faustino, Alberta Iglesias, Carmen Branca, Fernando Estrada, Alexandra Ferreira, Helena Front Microbiol Microbiology The emergence of infections (and colonization) with Enterobacteriaceae-producing carbapenemases is a threatening public health problem. In the last decades, we watched an isolated case becoming a brutal outbreak, a sporadic description becoming an endemic problem. The present study aims to highlight the dissemination of IMP-22-producing Klebsiella pneumoniae in the North of Portugal, through the phenotypic and genotypic characterization of isolates collected from hospitalized patients (n=5) and out-patients of the emergency ward of the same acute care hospital (n=2), and isolates responsible for the intestinal colonization of residents in a Long-Term Care Facility (n=4). Pulsed-field gel electrophoresis (PFGE) results, associated with conjugation experiments pointed to a pattern of both vertical and horizontal dissemination. Overall, and complementing other studies that give relevance to IMP-22-producing K. pneumoniae in the clinical settings, here we show for the first time the public health threatening breach of the hospital frontier of this resistance threat, toward the community. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8713047/ /pubmed/34970236 http://dx.doi.org/10.3389/fmicb.2021.777054 Text en Copyright © 2021 Gonçalves, Cecílio, Faustino, Iglesias, Branca, Estrada and Ferreira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Gonçalves, Daniela
Cecílio, Pedro
Faustino, Alberta
Iglesias, Carmen
Branca, Fernando
Estrada, Alexandra
Ferreira, Helena
Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title_full Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title_fullStr Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title_full_unstemmed Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title_short Intra- and Extra-Hospital Dissemination of IMP-22-Producing Klebsiella pneumoniae in Northern Portugal: The Breach of the Hospital Frontier Toward the Community
title_sort intra- and extra-hospital dissemination of imp-22-producing klebsiella pneumoniae in northern portugal: the breach of the hospital frontier toward the community
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713047/
https://www.ncbi.nlm.nih.gov/pubmed/34970236
http://dx.doi.org/10.3389/fmicb.2021.777054
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