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Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis
Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida species. In this review, we outline antifungal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713075/ https://www.ncbi.nlm.nih.gov/pubmed/34970504 http://dx.doi.org/10.3389/fcimb.2021.759408 |
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author | Murphy, Sarah E. Bicanic, Tihana |
author_facet | Murphy, Sarah E. Bicanic, Tihana |
author_sort | Murphy, Sarah E. |
collection | PubMed |
description | Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida species. In this review, we outline antifungal drugs already in clinical use for invasive candidiasis and candidaemia, their targets and mechanisms of resistance in clinically relevant Candida species, encompassing not only classical resistance, but also heteroresistance and tolerance. We describe novel antifungal agents and targets in pre-clinical and clinical development, including their spectrum of activity, antifungal target, clinical trial data and potential in treatment of drug-resistant Candida. Lastly, we discuss the use of combination therapy between conventional and repurposed agents as a potential strategy to combat the threat of emerging resistance in Candida. |
format | Online Article Text |
id | pubmed-8713075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87130752021-12-29 Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis Murphy, Sarah E. Bicanic, Tihana Front Cell Infect Microbiol Cellular and Infection Microbiology Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida species. In this review, we outline antifungal drugs already in clinical use for invasive candidiasis and candidaemia, their targets and mechanisms of resistance in clinically relevant Candida species, encompassing not only classical resistance, but also heteroresistance and tolerance. We describe novel antifungal agents and targets in pre-clinical and clinical development, including their spectrum of activity, antifungal target, clinical trial data and potential in treatment of drug-resistant Candida. Lastly, we discuss the use of combination therapy between conventional and repurposed agents as a potential strategy to combat the threat of emerging resistance in Candida. Frontiers Media S.A. 2021-12-14 /pmc/articles/PMC8713075/ /pubmed/34970504 http://dx.doi.org/10.3389/fcimb.2021.759408 Text en Copyright © 2021 Murphy and Bicanic https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Murphy, Sarah E. Bicanic, Tihana Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title | Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title_full | Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title_fullStr | Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title_full_unstemmed | Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title_short | Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis |
title_sort | drug resistance and novel therapeutic approaches in invasive candidiasis |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713075/ https://www.ncbi.nlm.nih.gov/pubmed/34970504 http://dx.doi.org/10.3389/fcimb.2021.759408 |
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