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Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression

BACKGROUND: The search of biomarkers in the field of depression requires easy implementable tests that are biologically rooted. Qualitative analysis of verbal fluency tests (VFT) are good candidates, but its cerebral correlates are unknown. METHODS: We collected qualitative semantic and phonemic VFT...

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Autores principales: Domain, L., Guillery, M., Linz, N., König, A., Batail, J.M., David, R., Corouge, I., Bannier, E., Ferré, J.C., Dondaine, T., Drapier, D., Robert, G.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713114/
https://www.ncbi.nlm.nih.gov/pubmed/34942588
http://dx.doi.org/10.1016/j.nicl.2021.102910
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author Domain, L.
Guillery, M.
Linz, N.
König, A.
Batail, J.M.
David, R.
Corouge, I.
Bannier, E.
Ferré, J.C.
Dondaine, T.
Drapier, D.
Robert, G.H.
author_facet Domain, L.
Guillery, M.
Linz, N.
König, A.
Batail, J.M.
David, R.
Corouge, I.
Bannier, E.
Ferré, J.C.
Dondaine, T.
Drapier, D.
Robert, G.H.
author_sort Domain, L.
collection PubMed
description BACKGROUND: The search of biomarkers in the field of depression requires easy implementable tests that are biologically rooted. Qualitative analysis of verbal fluency tests (VFT) are good candidates, but its cerebral correlates are unknown. METHODS: We collected qualitative semantic and phonemic VFT scores along with grey and white matter anatomical MRI of depressed (n = 26) and healthy controls (HC, n = 25) women. Qualitative VFT variables are the “clustering score” (i.e. the ability to produce words within subcategories) and the “switching score” (i.e. the ability to switch between clusters). The clustering and switching scores were automatically calculated using a data-driven approach. Brain measures were cortical thickness (CT) and fractional anisotropy (FA). We tested for associations between CT, FA and qualitative VFT variables within each group. RESULTS: Patients had reduced switching VFT scores compared to HC. Thicker cortex was associated with better switching score in semantic VFT bilaterally in the frontal (superior, rostral middle and inferior gyri), parietal (inferior parietal lobule including the supramarginal gyri), temporal (transverse and fusiform gyri) and occipital (lingual gyri) lobes in the depressed group. Positive association between FA and the switching score in semantic VFT was retrieved in depressed patients within the corpus callosum, right inferior fronto-occipital fasciculus, right superior longitudinal fasciculus extending to the anterior thalamic radiation (all p < 0.05, corrected). CONCLUSION: Together, these results suggest that automatic qualitative VFT scores are associated with brain anatomy and reinforce its potential use as a surrogate for depression cerebral bases.
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spelling pubmed-87131142022-01-05 Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression Domain, L. Guillery, M. Linz, N. König, A. Batail, J.M. David, R. Corouge, I. Bannier, E. Ferré, J.C. Dondaine, T. Drapier, D. Robert, G.H. Neuroimage Clin Regular Article BACKGROUND: The search of biomarkers in the field of depression requires easy implementable tests that are biologically rooted. Qualitative analysis of verbal fluency tests (VFT) are good candidates, but its cerebral correlates are unknown. METHODS: We collected qualitative semantic and phonemic VFT scores along with grey and white matter anatomical MRI of depressed (n = 26) and healthy controls (HC, n = 25) women. Qualitative VFT variables are the “clustering score” (i.e. the ability to produce words within subcategories) and the “switching score” (i.e. the ability to switch between clusters). The clustering and switching scores were automatically calculated using a data-driven approach. Brain measures were cortical thickness (CT) and fractional anisotropy (FA). We tested for associations between CT, FA and qualitative VFT variables within each group. RESULTS: Patients had reduced switching VFT scores compared to HC. Thicker cortex was associated with better switching score in semantic VFT bilaterally in the frontal (superior, rostral middle and inferior gyri), parietal (inferior parietal lobule including the supramarginal gyri), temporal (transverse and fusiform gyri) and occipital (lingual gyri) lobes in the depressed group. Positive association between FA and the switching score in semantic VFT was retrieved in depressed patients within the corpus callosum, right inferior fronto-occipital fasciculus, right superior longitudinal fasciculus extending to the anterior thalamic radiation (all p < 0.05, corrected). CONCLUSION: Together, these results suggest that automatic qualitative VFT scores are associated with brain anatomy and reinforce its potential use as a surrogate for depression cerebral bases. Elsevier 2021-12-06 /pmc/articles/PMC8713114/ /pubmed/34942588 http://dx.doi.org/10.1016/j.nicl.2021.102910 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Domain, L.
Guillery, M.
Linz, N.
König, A.
Batail, J.M.
David, R.
Corouge, I.
Bannier, E.
Ferré, J.C.
Dondaine, T.
Drapier, D.
Robert, G.H.
Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title_full Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title_fullStr Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title_full_unstemmed Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title_short Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression
title_sort multimodal mri cerebral correlates of verbal fluency switching and its impairment in women with depression
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713114/
https://www.ncbi.nlm.nih.gov/pubmed/34942588
http://dx.doi.org/10.1016/j.nicl.2021.102910
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