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Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

[Image: see text] Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin and Hippo signaling pathways that are involved in numerous human disease conditions including canc...

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Detalles Bibliográficos
Autores principales:	Leenders, Ruben G. G., Brinch, Shoshy Alam, Sowa, Sven T., Amundsen-Isaksen, Enya, Galera-Prat, Albert, Murthy, Sudarshan, Aertssen, Sjoerd, Smits, Johannes N., Nieczypor, Piotr, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Waaler, Jo, Krauss, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713164/ https://www.ncbi.nlm.nih.gov/pubmed/34878777 http://dx.doi.org/10.1021/acs.jmedchem.1c01264

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