New Insights into the Structure–Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na(+)/Ca(2+) Exchanger Isoforms

[Image: see text] Due to the neuroprotective role of the Na(+)/Ca(2+) exchanger (NCX) isoforms NCX1 and NCX3, we synthesized novel benzodiazepinone derivatives of the unique NCX activator Neurounina-1, named compounds 1–19. The derivatives are characterized by a benzodiazepinonic nucleus linked to f...

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Detalles Bibliográficos
Autores principales: Magli, Elisa, Fattorusso, Caterina, Persico, Marco, Corvino, Angela, Esposito, Gianluca, Fiorino, Ferdinando, Luciano, Paolo, Perissutti, Elisa, Santagada, Vincenzo, Severino, Beatrice, Tedeschi, Valentina, Pannaccione, Anna, Pignataro, Giuseppe, Caliendo, Giuseppe, Annunziato, Lucio, Secondo, Agnese, Frecentese, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713167/
https://www.ncbi.nlm.nih.gov/pubmed/34845907
http://dx.doi.org/10.1021/acs.jmedchem.1c01212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713167/
https://www.ncbi.nlm.nih.gov/pubmed/34845907
http://dx.doi.org/10.1021/acs.jmedchem.1c01212

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