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Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii
Toxoplasmosis is a zoonotic disease caused by the Toxoplasma gondii protozoan parasite. The aim of this study was to determine the frequency of acute toxoplasmosis or its presence in the medical history of 240 pregnant women, depending on age and geographical background. The second purpose was to an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713168/ https://www.ncbi.nlm.nih.gov/pubmed/34970346 http://dx.doi.org/10.3892/etm.2021.11046 |
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author | Csep, Andrei Vaida, Luminița Ligia Negruțiu, Bianca-Maria Todor, Bianca Ioana Judea-Pusta, Claudia Teodora Buhaș, Camelia Sava, Cristian |
author_facet | Csep, Andrei Vaida, Luminița Ligia Negruțiu, Bianca-Maria Todor, Bianca Ioana Judea-Pusta, Claudia Teodora Buhaș, Camelia Sava, Cristian |
author_sort | Csep, Andrei |
collection | PubMed |
description | Toxoplasmosis is a zoonotic disease caused by the Toxoplasma gondii protozoan parasite. The aim of this study was to determine the frequency of acute toxoplasmosis or its presence in the medical history of 240 pregnant women, depending on age and geographical background. The second purpose was to analyze several medical aspects (clinical and paraclinical) in pregnant women with acute toxoplasmosis. The study identified several serological changes including positive toxoplasma IgM, IgG, and IgA antibodies. The chemiluminescence immunoassay (CLIA) method was used to detect T. gondii-specific IgM and IgG antibodies and the enzyme immunoassay (EIA) method to detect T. gondii-specific IgA antibodies. Of the 96 pregnant women (40%) infected with T. gondii, approximately 1/3 had acquired acute infection and 2/3 had a history of prior acute infection (P<0.0001). No statistically significant differences according to age groups (P=0.9384) were found in terms of serological profile. The number of patients with negative serology was significantly higher in urban areas than in rural areas (P<0.0001). The highest incidence among the pregnant women with acute toxoplasmosis with a single chain of ganglia affected was represented by those with the involvement of cervical lymph nodes (75%), the difference compared to the involvement of other chains of ganglia being statistically significant (P=0.0087). All 35 pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgM antibodies. Most pregnant women with acute T. gondii infection (57.1%) tested negative for T. gondii-specific IgM antibody serum titres within 3-6 months of presentation. The difference compared to other intervals from the moment pregnant women sought care was statistically significant (P=00002). Only 80% of all pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgA antibodies. Pregnant women with acute toxoplasmosis have a 3.3 times higher risk of pregnancy loss. |
format | Online Article Text |
id | pubmed-8713168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-87131682021-12-29 Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii Csep, Andrei Vaida, Luminița Ligia Negruțiu, Bianca-Maria Todor, Bianca Ioana Judea-Pusta, Claudia Teodora Buhaș, Camelia Sava, Cristian Exp Ther Med Articles Toxoplasmosis is a zoonotic disease caused by the Toxoplasma gondii protozoan parasite. The aim of this study was to determine the frequency of acute toxoplasmosis or its presence in the medical history of 240 pregnant women, depending on age and geographical background. The second purpose was to analyze several medical aspects (clinical and paraclinical) in pregnant women with acute toxoplasmosis. The study identified several serological changes including positive toxoplasma IgM, IgG, and IgA antibodies. The chemiluminescence immunoassay (CLIA) method was used to detect T. gondii-specific IgM and IgG antibodies and the enzyme immunoassay (EIA) method to detect T. gondii-specific IgA antibodies. Of the 96 pregnant women (40%) infected with T. gondii, approximately 1/3 had acquired acute infection and 2/3 had a history of prior acute infection (P<0.0001). No statistically significant differences according to age groups (P=0.9384) were found in terms of serological profile. The number of patients with negative serology was significantly higher in urban areas than in rural areas (P<0.0001). The highest incidence among the pregnant women with acute toxoplasmosis with a single chain of ganglia affected was represented by those with the involvement of cervical lymph nodes (75%), the difference compared to the involvement of other chains of ganglia being statistically significant (P=0.0087). All 35 pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgM antibodies. Most pregnant women with acute T. gondii infection (57.1%) tested negative for T. gondii-specific IgM antibody serum titres within 3-6 months of presentation. The difference compared to other intervals from the moment pregnant women sought care was statistically significant (P=00002). Only 80% of all pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgA antibodies. Pregnant women with acute toxoplasmosis have a 3.3 times higher risk of pregnancy loss. D.A. Spandidos 2022-02 2021-12-07 /pmc/articles/PMC8713168/ /pubmed/34970346 http://dx.doi.org/10.3892/etm.2021.11046 Text en Copyright: © Csep et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Csep, Andrei Vaida, Luminița Ligia Negruțiu, Bianca-Maria Todor, Bianca Ioana Judea-Pusta, Claudia Teodora Buhaș, Camelia Sava, Cristian Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title | Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title_full | Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title_fullStr | Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title_full_unstemmed | Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title_short | Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii |
title_sort | research on demographic, clinical and paraclinical aspects in pregnant women infected with toxoplasma gondii |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713168/ https://www.ncbi.nlm.nih.gov/pubmed/34970346 http://dx.doi.org/10.3892/etm.2021.11046 |
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