Electrostatics Drive Oligomerization and Aggregation of Human Interferon Alpha-2a

[Image: see text] Aggregation is a common phenomenon in the field of protein therapeutics and can lead to function loss or immunogenic patient responses. Two strategies are currently used to reduce aggregation: (1) finding a suitable formulation, which is labor-intensive and requires large protein q...

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Detalles Bibliográficos
Autores principales: Pohl, Christin, Polimeni, Marco, Indrakumar, Sowmya, Streicher, Werner, Peters, Günther H.J., Nørgaard, Allan, Lund, Mikael, Harris, Pernille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713289/
https://www.ncbi.nlm.nih.gov/pubmed/34898211
http://dx.doi.org/10.1021/acs.jpcb.1c07090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713289/
https://www.ncbi.nlm.nih.gov/pubmed/34898211
http://dx.doi.org/10.1021/acs.jpcb.1c07090

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