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Electrostatics Drive Oligomerization and Aggregation of Human Interferon Alpha-2a

[Image: see text] Aggregation is a common phenomenon in the field of protein therapeutics and can lead to function loss or immunogenic patient responses. Two strategies are currently used to reduce aggregation: (1) finding a suitable formulation, which is labor-intensive and requires large protein q...

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Detalles Bibliográficos
Autores principales:	Pohl, Christin, Polimeni, Marco, Indrakumar, Sowmya, Streicher, Werner, Peters, Günther H.J., Nørgaard, Allan, Lund, Mikael, Harris, Pernille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713289/ https://www.ncbi.nlm.nih.gov/pubmed/34898211 http://dx.doi.org/10.1021/acs.jpcb.1c07090

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