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Mesenchymal stem cell-derived exosomes for gastrointestinal cancer

Gastrointestinal (GI) malignancies, a series of malignant conditions originating from the digestive system, include gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. GI cancers have been regarded as the leading cancer-related cause of death in recent years. Therefor...

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Autores principales: Zhao, Lin-Xian, Zhang, Kai, Shen, Bing-Bing, Li, Jian-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713327/
https://www.ncbi.nlm.nih.gov/pubmed/35070036
http://dx.doi.org/10.4251/wjgo.v13.i12.1981
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author Zhao, Lin-Xian
Zhang, Kai
Shen, Bing-Bing
Li, Jian-Nan
author_facet Zhao, Lin-Xian
Zhang, Kai
Shen, Bing-Bing
Li, Jian-Nan
author_sort Zhao, Lin-Xian
collection PubMed
description Gastrointestinal (GI) malignancies, a series of malignant conditions originating from the digestive system, include gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. GI cancers have been regarded as the leading cancer-related cause of death in recent years. Therefore, it is essential to develop effective treatment strategies for GI malignancies. Mesenchymal stem cells (MSCs), a type of distinct non-hematopoietic stem cells and an important component of the tumor microenvironment, play important roles in regulating GI cancer development and progression through multiple mechanisms, such as secreting cytokines and direct interactions. Currently, studies are focusing on the anti-cancer effect of MSCs on GI malignancies. However, the effects and functional mechanisms of MSC-derived exosomes on GI cancer are less studied. MSC-derived exosomes can regulate GI tumor growth, drug response, metastasis, and invasion through transplanting proteins and miRNA to tumor cells to activate the specific signal pathway. Besides, the MSC-derived exosomes are also seen as an important drug delivery system and have shown potential in anti-cancer treatment. This study aims to summarize the effect and biological functions of MSC-derived exosomes on the development of GI cancers and discuss their possible clinical applications for the treatment of GI malignancies.
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spelling pubmed-87133272022-01-20 Mesenchymal stem cell-derived exosomes for gastrointestinal cancer Zhao, Lin-Xian Zhang, Kai Shen, Bing-Bing Li, Jian-Nan World J Gastrointest Oncol Review Gastrointestinal (GI) malignancies, a series of malignant conditions originating from the digestive system, include gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. GI cancers have been regarded as the leading cancer-related cause of death in recent years. Therefore, it is essential to develop effective treatment strategies for GI malignancies. Mesenchymal stem cells (MSCs), a type of distinct non-hematopoietic stem cells and an important component of the tumor microenvironment, play important roles in regulating GI cancer development and progression through multiple mechanisms, such as secreting cytokines and direct interactions. Currently, studies are focusing on the anti-cancer effect of MSCs on GI malignancies. However, the effects and functional mechanisms of MSC-derived exosomes on GI cancer are less studied. MSC-derived exosomes can regulate GI tumor growth, drug response, metastasis, and invasion through transplanting proteins and miRNA to tumor cells to activate the specific signal pathway. Besides, the MSC-derived exosomes are also seen as an important drug delivery system and have shown potential in anti-cancer treatment. This study aims to summarize the effect and biological functions of MSC-derived exosomes on the development of GI cancers and discuss their possible clinical applications for the treatment of GI malignancies. Baishideng Publishing Group Inc 2021-12-15 2021-12-15 /pmc/articles/PMC8713327/ /pubmed/35070036 http://dx.doi.org/10.4251/wjgo.v13.i12.1981 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Zhao, Lin-Xian
Zhang, Kai
Shen, Bing-Bing
Li, Jian-Nan
Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title_full Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title_fullStr Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title_full_unstemmed Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title_short Mesenchymal stem cell-derived exosomes for gastrointestinal cancer
title_sort mesenchymal stem cell-derived exosomes for gastrointestinal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713327/
https://www.ncbi.nlm.nih.gov/pubmed/35070036
http://dx.doi.org/10.4251/wjgo.v13.i12.1981
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