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Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-base...

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Detalles Bibliográficos
Autores principales:	Aziz, Yasmine M. Abdel, Lotfy, Gehad, Said, Mohamed M., El Ashry, El Sayed H., El Tamany, El Sayed H., Soliman, Saied M., Abu-Serie, Marwa M., Teleb, Mohamed, Yousuf, Sammer, Dömling, Alexander, Domingo, Luis R., Barakat, Assem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713455/ https://www.ncbi.nlm.nih.gov/pubmed/34970530 http://dx.doi.org/10.3389/fchem.2021.735236

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