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GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response
Lung cancer is one of the most common and mortal malignancies, usually with a poor prognosis in its advanced or recurrent stages. Recently, immune checkpoint inhibitors (ICIs) immunotherapy has revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD), and significantly impr...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713481/ https://www.ncbi.nlm.nih.gov/pubmed/34970479 http://dx.doi.org/10.3389/fonc.2021.733533 |
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author | Leng, Yang Dang, Shiying Yin, Fei Gao, Tianshun Xiao, Xing Zhang, Yi Chen, Lin Qin, Changfei Lai, Nannan Zhan, Xiao-Yong Huang, Ke Luo, Chuanming Kang, Yang Wang, Nan Li, Yun Liang, Yuhong Huang, Bihui |
author_facet | Leng, Yang Dang, Shiying Yin, Fei Gao, Tianshun Xiao, Xing Zhang, Yi Chen, Lin Qin, Changfei Lai, Nannan Zhan, Xiao-Yong Huang, Ke Luo, Chuanming Kang, Yang Wang, Nan Li, Yun Liang, Yuhong Huang, Bihui |
author_sort | Leng, Yang |
collection | PubMed |
description | Lung cancer is one of the most common and mortal malignancies, usually with a poor prognosis in its advanced or recurrent stages. Recently, immune checkpoint inhibitors (ICIs) immunotherapy has revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD), and significantly improved patients’ prognoses. However, the prognostic and predictive outcomes differ because of tumor heterogeneity. Here, we present an effective method, GDPLichi (Genes of DNA damage repair to predict LUAD immune checkpoint inhibitors response), as the signature to predict the LUAD patient’s response to the ICIs. GDPLichi utilized only 7 maker genes from 8 DDR pathways to construct the predictive model and classified LUAD patients into two subgroups: low- and high-risk groups. The high-risk group was featured by worse prognosis and decreased B cells, CD8(+) T cells, CD8(+) central memory T cells, hematopoietic stem cells (HSC), myeloid dendritic cells (MDC), and immune scores as compared to the low-risk group. However, our research also suggests that the high-risk group was more sensitive to ICIs, which might be explained by increased TMB, neoantigen, immune checkpoint molecules, and immune suppression genes’ expression, but lower TIDE score as compared to the low-risk group. This conclusion was verified in three other LUAD cohort datasets (GSE30219, GSE31210, GSE50081). |
format | Online Article Text |
id | pubmed-8713481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87134812021-12-29 GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response Leng, Yang Dang, Shiying Yin, Fei Gao, Tianshun Xiao, Xing Zhang, Yi Chen, Lin Qin, Changfei Lai, Nannan Zhan, Xiao-Yong Huang, Ke Luo, Chuanming Kang, Yang Wang, Nan Li, Yun Liang, Yuhong Huang, Bihui Front Oncol Oncology Lung cancer is one of the most common and mortal malignancies, usually with a poor prognosis in its advanced or recurrent stages. Recently, immune checkpoint inhibitors (ICIs) immunotherapy has revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD), and significantly improved patients’ prognoses. However, the prognostic and predictive outcomes differ because of tumor heterogeneity. Here, we present an effective method, GDPLichi (Genes of DNA damage repair to predict LUAD immune checkpoint inhibitors response), as the signature to predict the LUAD patient’s response to the ICIs. GDPLichi utilized only 7 maker genes from 8 DDR pathways to construct the predictive model and classified LUAD patients into two subgroups: low- and high-risk groups. The high-risk group was featured by worse prognosis and decreased B cells, CD8(+) T cells, CD8(+) central memory T cells, hematopoietic stem cells (HSC), myeloid dendritic cells (MDC), and immune scores as compared to the low-risk group. However, our research also suggests that the high-risk group was more sensitive to ICIs, which might be explained by increased TMB, neoantigen, immune checkpoint molecules, and immune suppression genes’ expression, but lower TIDE score as compared to the low-risk group. This conclusion was verified in three other LUAD cohort datasets (GSE30219, GSE31210, GSE50081). Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8713481/ /pubmed/34970479 http://dx.doi.org/10.3389/fonc.2021.733533 Text en Copyright © 2021 Leng, Dang, Yin, Gao, Xiao, Zhang, Chen, Qin, Lai, Zhan, Huang, Luo, Kang, Wang, Li, Liang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Leng, Yang Dang, Shiying Yin, Fei Gao, Tianshun Xiao, Xing Zhang, Yi Chen, Lin Qin, Changfei Lai, Nannan Zhan, Xiao-Yong Huang, Ke Luo, Chuanming Kang, Yang Wang, Nan Li, Yun Liang, Yuhong Huang, Bihui GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title | GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title_full | GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title_fullStr | GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title_full_unstemmed | GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title_short | GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response |
title_sort | gdplichi: a dna damage repair-related gene classifier for predicting lung adenocarcinoma immune checkpoint inhibitors response |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713481/ https://www.ncbi.nlm.nih.gov/pubmed/34970479 http://dx.doi.org/10.3389/fonc.2021.733533 |
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