Severe Type of COVID-19: Pathogenesis, Warning Indicators and Treatment

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a major public health issue. The epidemic is unlikely to be contained until the global launch of safe and effective vaccines that could prevent serious illnesses and provide herd immunity. Although most patients have mild flu-like symptoms, some develop severe illnesses accompanied by multiple organ dysfunction. The identification of pathophysiology and early warning biomarkers of a severe type of COVID-19 contribute to the treatment and prevention of serious complications. Here, we review the pathophysiology, early warning indicators, and effective treatment of Chinese and Western Medicine for patients with a severe type of COVID-19. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material (Appendix 1) is available in the online version of this article at DOI: 10.1007/s11655-021-3313-x.