Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides

Steric-blocking oligonucleotides (SBOs) are short, single-stranded nucleic acids designed to modulate gene expression by binding to RNA transcripts and blocking access from cellular machinery such as splicing factors. SBOs have the potential to bind to near-complementary sites in the transcriptome,...

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Detalles Bibliográficos
Autores principales: Holgersen, Erle M., Gandhi, Shreshth, Zhou, Yongchao, Kim, Jinkuk, Vaz, Brandon, Bogojeski, Jovanka, Bugno, Magdalena, Shalev, Zvi, Cheung-Ong, Kahlin, Gonçalves, João, O'Hara, Matthew, Kron, Ken, Verby, Marta, Sun, Mark, Kakaradov, Boyko, Delong, Andrew, Merico, Daniele, Deshwar, Amit G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713556/
https://www.ncbi.nlm.nih.gov/pubmed/34388351
http://dx.doi.org/10.1089/nat.2020.0921

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