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Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers
Phosphorothioate (PS) modification of antisense oligonucleotides (ASOs) is a critical factor enabling their therapeutic use. Standard chemical synthesis incorporates this group in a stereorandom manner; however, significant effort was made over the years to establish and characterize the impact of c...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Mary Ann Liebert, Inc., publishers
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713576/ https://www.ncbi.nlm.nih.gov/pubmed/34619060 http://dx.doi.org/10.1089/nat.2021.0055 |