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Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory, and radiographic data along with longitudinal biologic sampling of blood and re...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713959/ https://www.ncbi.nlm.nih.gov/pubmed/34376480 http://dx.doi.org/10.1126/sciimmunol.abf3733 |
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| author | Rouphael, Nadine Maecker, Holden Montgomery, Ruth R. Diray-Arce, Joann Kleinstein, Steven H. Altman, Matthew C. Bosinger, Steven E. Eckalbar, Walter Guan, Leying Hough, Catherine L. Krammer, Florian Langelier, Charles Levy, Ofer McEnaney, Kerry Peters, Bjoern Rahman, Adeeb Rajan, Jayant V. Sigelman, Steven Steen, Hanno van Bakel, Harm Ward, Alyssa Wilson, Michael R. Woodruff, Prescott Zamecnik, Colin R. Augustine, Alison D. Ozonoff, Al Reed, Elaine F. Becker, Patrice M. Higuita, Nelson Agudelo Altman, Matthew C. Atkinson, Mark A. Baden, Lindsey R. Becker, Patrice M. Bime, Christian Brakenridge, Scott C. Calfee, Carolyn S. Cairns, Charles B. Corry, David Davis, Mark M. Augustine, Alison D. Ehrlich, Lauren I. R. Haddad, Elias K. Erle, David J. Fernandez-Sesma, Ana Hafler, David A. Hough, Catherine L. Kheradmand, Farrah Kleinstein, Steven H. Kraft, Monica Levy, Ofer McComsey, Grace A. Melamed, Esther Messer, William Metcalf, Jordan Montgomery, Ruth R. Nadeau, Kari C. Ozonoff, Al Peters, Bjoern Pulendran, Bali Reed, Elaine F. Rouphael, Nadine Sarwal, Minnie Schaenman, Joanna Sekaly, Rafick Shaw, Albert C. Simon, Viviana |
| author_facet | Rouphael, Nadine Maecker, Holden Montgomery, Ruth R. Diray-Arce, Joann Kleinstein, Steven H. Altman, Matthew C. Bosinger, Steven E. Eckalbar, Walter Guan, Leying Hough, Catherine L. Krammer, Florian Langelier, Charles Levy, Ofer McEnaney, Kerry Peters, Bjoern Rahman, Adeeb Rajan, Jayant V. Sigelman, Steven Steen, Hanno van Bakel, Harm Ward, Alyssa Wilson, Michael R. Woodruff, Prescott Zamecnik, Colin R. Augustine, Alison D. Ozonoff, Al Reed, Elaine F. Becker, Patrice M. Higuita, Nelson Agudelo Altman, Matthew C. Atkinson, Mark A. Baden, Lindsey R. Becker, Patrice M. Bime, Christian Brakenridge, Scott C. Calfee, Carolyn S. Cairns, Charles B. Corry, David Davis, Mark M. Augustine, Alison D. Ehrlich, Lauren I. R. Haddad, Elias K. Erle, David J. Fernandez-Sesma, Ana Hafler, David A. Hough, Catherine L. Kheradmand, Farrah Kleinstein, Steven H. Kraft, Monica Levy, Ofer McComsey, Grace A. Melamed, Esther Messer, William Metcalf, Jordan Montgomery, Ruth R. Nadeau, Kari C. Ozonoff, Al Peters, Bjoern Pulendran, Bali Reed, Elaine F. Rouphael, Nadine Sarwal, Minnie Schaenman, Joanna Sekaly, Rafick Shaw, Albert C. Simon, Viviana |
| collection | PubMed |
| description | The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory, and radiographic data along with longitudinal biologic sampling of blood and respiratory secretions for in-depth testing. Clinical and laboratory data are integrated to identify immunologic, virologic, proteomic, metabolomic, and genomic features of COVID-19–related susceptibility, severity, and disease progression. The goals of IMPACC are to better understand the contributions of pathogen dynamics and host immune responses to the severity and course of COVID-19 and to generate hypotheses for identification of biomarkers and effective therapeutics, including optimal timing of such interventions. In this report, we summarize the IMPACC study design and protocols including clinical criteria and recruitment, multisite standardized sample collection and processing, virologic and immunologic assays, harmonization of assay protocols, high-level analyses, and the data sharing plans. |
| format | Online Article Text |
| id | pubmed-8713959 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87139592022-01-06 Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study Rouphael, Nadine Maecker, Holden Montgomery, Ruth R. Diray-Arce, Joann Kleinstein, Steven H. Altman, Matthew C. Bosinger, Steven E. Eckalbar, Walter Guan, Leying Hough, Catherine L. Krammer, Florian Langelier, Charles Levy, Ofer McEnaney, Kerry Peters, Bjoern Rahman, Adeeb Rajan, Jayant V. Sigelman, Steven Steen, Hanno van Bakel, Harm Ward, Alyssa Wilson, Michael R. Woodruff, Prescott Zamecnik, Colin R. Augustine, Alison D. Ozonoff, Al Reed, Elaine F. Becker, Patrice M. Higuita, Nelson Agudelo Altman, Matthew C. Atkinson, Mark A. Baden, Lindsey R. Becker, Patrice M. Bime, Christian Brakenridge, Scott C. Calfee, Carolyn S. Cairns, Charles B. Corry, David Davis, Mark M. Augustine, Alison D. Ehrlich, Lauren I. R. Haddad, Elias K. Erle, David J. Fernandez-Sesma, Ana Hafler, David A. Hough, Catherine L. Kheradmand, Farrah Kleinstein, Steven H. Kraft, Monica Levy, Ofer McComsey, Grace A. Melamed, Esther Messer, William Metcalf, Jordan Montgomery, Ruth R. Nadeau, Kari C. Ozonoff, Al Peters, Bjoern Pulendran, Bali Reed, Elaine F. Rouphael, Nadine Sarwal, Minnie Schaenman, Joanna Sekaly, Rafick Shaw, Albert C. Simon, Viviana Sci Immunol Research Resources The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory, and radiographic data along with longitudinal biologic sampling of blood and respiratory secretions for in-depth testing. Clinical and laboratory data are integrated to identify immunologic, virologic, proteomic, metabolomic, and genomic features of COVID-19–related susceptibility, severity, and disease progression. The goals of IMPACC are to better understand the contributions of pathogen dynamics and host immune responses to the severity and course of COVID-19 and to generate hypotheses for identification of biomarkers and effective therapeutics, including optimal timing of such interventions. In this report, we summarize the IMPACC study design and protocols including clinical criteria and recruitment, multisite standardized sample collection and processing, virologic and immunologic assays, harmonization of assay protocols, high-level analyses, and the data sharing plans. American Association for the Advancement of Science 2021-08-10 /pmc/articles/PMC8713959/ /pubmed/34376480 http://dx.doi.org/10.1126/sciimmunol.abf3733 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Resources Rouphael, Nadine Maecker, Holden Montgomery, Ruth R. Diray-Arce, Joann Kleinstein, Steven H. Altman, Matthew C. Bosinger, Steven E. Eckalbar, Walter Guan, Leying Hough, Catherine L. Krammer, Florian Langelier, Charles Levy, Ofer McEnaney, Kerry Peters, Bjoern Rahman, Adeeb Rajan, Jayant V. Sigelman, Steven Steen, Hanno van Bakel, Harm Ward, Alyssa Wilson, Michael R. Woodruff, Prescott Zamecnik, Colin R. Augustine, Alison D. Ozonoff, Al Reed, Elaine F. Becker, Patrice M. Higuita, Nelson Agudelo Altman, Matthew C. Atkinson, Mark A. Baden, Lindsey R. Becker, Patrice M. Bime, Christian Brakenridge, Scott C. Calfee, Carolyn S. Cairns, Charles B. Corry, David Davis, Mark M. Augustine, Alison D. Ehrlich, Lauren I. R. Haddad, Elias K. Erle, David J. Fernandez-Sesma, Ana Hafler, David A. Hough, Catherine L. Kheradmand, Farrah Kleinstein, Steven H. Kraft, Monica Levy, Ofer McComsey, Grace A. Melamed, Esther Messer, William Metcalf, Jordan Montgomery, Ruth R. Nadeau, Kari C. Ozonoff, Al Peters, Bjoern Pulendran, Bali Reed, Elaine F. Rouphael, Nadine Sarwal, Minnie Schaenman, Joanna Sekaly, Rafick Shaw, Albert C. Simon, Viviana Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title | Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title_full | Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title_fullStr | Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title_full_unstemmed | Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title_short | Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study |
| title_sort | immunophenotyping assessment in a covid-19 cohort (impacc): a prospective longitudinal study |
| topic | Research Resources |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713959/ https://www.ncbi.nlm.nih.gov/pubmed/34376480 http://dx.doi.org/10.1126/sciimmunol.abf3733 |
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