Cargando…

Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study

BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adhere...

Descripción completa

Detalles Bibliográficos
Autores principales: Minwagaw, Molalign Tarekegn, Akenie, Betelihem Belete, Tewabe, Desalew Salew, Tegegne, Awoke Seyoum, Beyene, Tariku Belachew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713999/
https://www.ncbi.nlm.nih.gov/pubmed/34992354
http://dx.doi.org/10.2147/PPA.S339108
_version_ 1784623827387416576
author Minwagaw, Molalign Tarekegn
Akenie, Betelihem Belete
Tewabe, Desalew Salew
Tegegne, Awoke Seyoum
Beyene, Tariku Belachew
author_facet Minwagaw, Molalign Tarekegn
Akenie, Betelihem Belete
Tewabe, Desalew Salew
Tegegne, Awoke Seyoum
Beyene, Tariku Belachew
author_sort Minwagaw, Molalign Tarekegn
collection PubMed
description BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adherence to CART and treatment failure at second-line regimen among adults living with HIV/AIDS in public hospitals of Amhara region, north-western Ethiopia. METHODS: A retrospective cohort study design was conducted on 700 HIV-positive people who were receiving a second-line CART regimen. Participants on second-line regimens who followed their treatment between 2016 and 2019 were considered. Data were extracted from participants’ clinical charts from June 18–July 7, 2020. RESULTS: A multivariate regression analysis indicates that age of patients (OR = 1.025, 95% CI: 1.001–1.321; p = 0.005), follow-up visits (OR = 0.979, 95% CI: 0.873–0.998; p < 0.001), CD4 cell count change (OR = 0.9860; 95% CI: 0.835–0.998; p < 0.01), marital status (OR = 0.973, 95% CI: 0.789– 0.997; p = 0.006), female HIV-infected patients (OR = 0.990; 95% CI: 0.789–0.999; p <0.001), rural patients (OR = 1.151; 95% CI 1.065–1.398; p = 0.004), non-educated adult patients (OR = 1.026, 95% CI: 1.002–1.198; p = 0.003), existence of social violence (OR = 0.012, 95% CI: 0.008–0.134; p< 0.01), patients with opportunistic diseases (OR = 1.0345, 95% CI 1.002–1.142; p = 0.001), CD4 cell count (OR = 0.901, 95% CI: 0.843–0.995; p = 0.025) and malnutrition (OR = 0.883, 95% CI; 0.762–0.954; p = 0.001) significantly affected the two response variables. CONCLUSION: Several variables affected both poor adherence to HAART and treatment failure at second-line regimens in the current investigation. Due attention should be given to aged patients, rural residents, non-educated patients, and patients with other morbidities to be successful with second-line treatment regimens.
format Online
Article
Text
id pubmed-8713999
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-87139992022-01-05 Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study Minwagaw, Molalign Tarekegn Akenie, Betelihem Belete Tewabe, Desalew Salew Tegegne, Awoke Seyoum Beyene, Tariku Belachew Patient Prefer Adherence Original Research BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adherence to CART and treatment failure at second-line regimen among adults living with HIV/AIDS in public hospitals of Amhara region, north-western Ethiopia. METHODS: A retrospective cohort study design was conducted on 700 HIV-positive people who were receiving a second-line CART regimen. Participants on second-line regimens who followed their treatment between 2016 and 2019 were considered. Data were extracted from participants’ clinical charts from June 18–July 7, 2020. RESULTS: A multivariate regression analysis indicates that age of patients (OR = 1.025, 95% CI: 1.001–1.321; p = 0.005), follow-up visits (OR = 0.979, 95% CI: 0.873–0.998; p < 0.001), CD4 cell count change (OR = 0.9860; 95% CI: 0.835–0.998; p < 0.01), marital status (OR = 0.973, 95% CI: 0.789– 0.997; p = 0.006), female HIV-infected patients (OR = 0.990; 95% CI: 0.789–0.999; p <0.001), rural patients (OR = 1.151; 95% CI 1.065–1.398; p = 0.004), non-educated adult patients (OR = 1.026, 95% CI: 1.002–1.198; p = 0.003), existence of social violence (OR = 0.012, 95% CI: 0.008–0.134; p< 0.01), patients with opportunistic diseases (OR = 1.0345, 95% CI 1.002–1.142; p = 0.001), CD4 cell count (OR = 0.901, 95% CI: 0.843–0.995; p = 0.025) and malnutrition (OR = 0.883, 95% CI; 0.762–0.954; p = 0.001) significantly affected the two response variables. CONCLUSION: Several variables affected both poor adherence to HAART and treatment failure at second-line regimens in the current investigation. Due attention should be given to aged patients, rural residents, non-educated patients, and patients with other morbidities to be successful with second-line treatment regimens. Dove 2021-12-24 /pmc/articles/PMC8713999/ /pubmed/34992354 http://dx.doi.org/10.2147/PPA.S339108 Text en © 2021 Minwagaw et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Minwagaw, Molalign Tarekegn
Akenie, Betelihem Belete
Tewabe, Desalew Salew
Tegegne, Awoke Seyoum
Beyene, Tariku Belachew
Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title_full Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title_fullStr Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title_full_unstemmed Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title_short Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
title_sort predictors of poor adherence to cart and treatment failure at second-line regimens among adults in public hospitals of amhara region, north-western ethiopia: a retrospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713999/
https://www.ncbi.nlm.nih.gov/pubmed/34992354
http://dx.doi.org/10.2147/PPA.S339108
work_keys_str_mv AT minwagawmolaligntarekegn predictorsofpooradherencetocartandtreatmentfailureatsecondlineregimensamongadultsinpublichospitalsofamhararegionnorthwesternethiopiaaretrospectivecohortstudy
AT akeniebetelihembelete predictorsofpooradherencetocartandtreatmentfailureatsecondlineregimensamongadultsinpublichospitalsofamhararegionnorthwesternethiopiaaretrospectivecohortstudy
AT tewabedesalewsalew predictorsofpooradherencetocartandtreatmentfailureatsecondlineregimensamongadultsinpublichospitalsofamhararegionnorthwesternethiopiaaretrospectivecohortstudy
AT tegegneawokeseyoum predictorsofpooradherencetocartandtreatmentfailureatsecondlineregimensamongadultsinpublichospitalsofamhararegionnorthwesternethiopiaaretrospectivecohortstudy
AT beyenetarikubelachew predictorsofpooradherencetocartandtreatmentfailureatsecondlineregimensamongadultsinpublichospitalsofamhararegionnorthwesternethiopiaaretrospectivecohortstudy