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Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study
BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adhere...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713999/ https://www.ncbi.nlm.nih.gov/pubmed/34992354 http://dx.doi.org/10.2147/PPA.S339108 |
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author | Minwagaw, Molalign Tarekegn Akenie, Betelihem Belete Tewabe, Desalew Salew Tegegne, Awoke Seyoum Beyene, Tariku Belachew |
author_facet | Minwagaw, Molalign Tarekegn Akenie, Betelihem Belete Tewabe, Desalew Salew Tegegne, Awoke Seyoum Beyene, Tariku Belachew |
author_sort | Minwagaw, Molalign Tarekegn |
collection | PubMed |
description | BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adherence to CART and treatment failure at second-line regimen among adults living with HIV/AIDS in public hospitals of Amhara region, north-western Ethiopia. METHODS: A retrospective cohort study design was conducted on 700 HIV-positive people who were receiving a second-line CART regimen. Participants on second-line regimens who followed their treatment between 2016 and 2019 were considered. Data were extracted from participants’ clinical charts from June 18–July 7, 2020. RESULTS: A multivariate regression analysis indicates that age of patients (OR = 1.025, 95% CI: 1.001–1.321; p = 0.005), follow-up visits (OR = 0.979, 95% CI: 0.873–0.998; p < 0.001), CD4 cell count change (OR = 0.9860; 95% CI: 0.835–0.998; p < 0.01), marital status (OR = 0.973, 95% CI: 0.789– 0.997; p = 0.006), female HIV-infected patients (OR = 0.990; 95% CI: 0.789–0.999; p <0.001), rural patients (OR = 1.151; 95% CI 1.065–1.398; p = 0.004), non-educated adult patients (OR = 1.026, 95% CI: 1.002–1.198; p = 0.003), existence of social violence (OR = 0.012, 95% CI: 0.008–0.134; p< 0.01), patients with opportunistic diseases (OR = 1.0345, 95% CI 1.002–1.142; p = 0.001), CD4 cell count (OR = 0.901, 95% CI: 0.843–0.995; p = 0.025) and malnutrition (OR = 0.883, 95% CI; 0.762–0.954; p = 0.001) significantly affected the two response variables. CONCLUSION: Several variables affected both poor adherence to HAART and treatment failure at second-line regimens in the current investigation. Due attention should be given to aged patients, rural residents, non-educated patients, and patients with other morbidities to be successful with second-line treatment regimens. |
format | Online Article Text |
id | pubmed-8713999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-87139992022-01-05 Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study Minwagaw, Molalign Tarekegn Akenie, Betelihem Belete Tewabe, Desalew Salew Tegegne, Awoke Seyoum Beyene, Tariku Belachew Patient Prefer Adherence Original Research BACKGROUND: Globally, HIV/AIDS has challenged the lives of 36.3 million people and resulted in 17 million orphans. The disease has neither a vaccine nor a cure and the only option currently is highly active antiretroviral therapy. This research was conducted to identify the predictors of poor adherence to CART and treatment failure at second-line regimen among adults living with HIV/AIDS in public hospitals of Amhara region, north-western Ethiopia. METHODS: A retrospective cohort study design was conducted on 700 HIV-positive people who were receiving a second-line CART regimen. Participants on second-line regimens who followed their treatment between 2016 and 2019 were considered. Data were extracted from participants’ clinical charts from June 18–July 7, 2020. RESULTS: A multivariate regression analysis indicates that age of patients (OR = 1.025, 95% CI: 1.001–1.321; p = 0.005), follow-up visits (OR = 0.979, 95% CI: 0.873–0.998; p < 0.001), CD4 cell count change (OR = 0.9860; 95% CI: 0.835–0.998; p < 0.01), marital status (OR = 0.973, 95% CI: 0.789– 0.997; p = 0.006), female HIV-infected patients (OR = 0.990; 95% CI: 0.789–0.999; p <0.001), rural patients (OR = 1.151; 95% CI 1.065–1.398; p = 0.004), non-educated adult patients (OR = 1.026, 95% CI: 1.002–1.198; p = 0.003), existence of social violence (OR = 0.012, 95% CI: 0.008–0.134; p< 0.01), patients with opportunistic diseases (OR = 1.0345, 95% CI 1.002–1.142; p = 0.001), CD4 cell count (OR = 0.901, 95% CI: 0.843–0.995; p = 0.025) and malnutrition (OR = 0.883, 95% CI; 0.762–0.954; p = 0.001) significantly affected the two response variables. CONCLUSION: Several variables affected both poor adherence to HAART and treatment failure at second-line regimens in the current investigation. Due attention should be given to aged patients, rural residents, non-educated patients, and patients with other morbidities to be successful with second-line treatment regimens. Dove 2021-12-24 /pmc/articles/PMC8713999/ /pubmed/34992354 http://dx.doi.org/10.2147/PPA.S339108 Text en © 2021 Minwagaw et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Minwagaw, Molalign Tarekegn Akenie, Betelihem Belete Tewabe, Desalew Salew Tegegne, Awoke Seyoum Beyene, Tariku Belachew Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title | Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title_full | Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title_fullStr | Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title_full_unstemmed | Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title_short | Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study |
title_sort | predictors of poor adherence to cart and treatment failure at second-line regimens among adults in public hospitals of amhara region, north-western ethiopia: a retrospective cohort study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713999/ https://www.ncbi.nlm.nih.gov/pubmed/34992354 http://dx.doi.org/10.2147/PPA.S339108 |
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