SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its target genes have remained largely elusive. Here, we identify the SMAD4 target genes in mouse limb buds using an epitope-tagged Smad4 allele for ChIP-seq anal...

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Detalles Bibliográficos
Autores principales: Gamart, Julie, Barozzi, Iros, Laurent, Frédéric, Reinhardt, Robert, Martins, Laurène Ramos, Oberholzer, Thomas, Visel, Axel, Zeller, Rolf, Zuniga, Aimée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714076/
https://www.ncbi.nlm.nih.gov/pubmed/34822715
http://dx.doi.org/10.1242/dev.200182

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