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TM2D genes regulate Notch signaling and neuronal function in Drosophila

TM2 domain containing (TM2D) proteins are conserved in metazoans and encoded by three separate genes in each model organism species that has been sequenced. Rare variants in TM2D3 are associated with Alzheimer’s disease (AD) and its fly ortholog almondex is required for embryonic Notch signaling. Ho...

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Detalles Bibliográficos
Autores principales:	Salazar, Jose L., Yang, Sheng-An, Lin, Yong Qi, Li-Kroeger, David, Marcogliese, Paul C., Deal, Samantha L., Neely, G. Gregory, Yamamoto, Shinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714088/ https://www.ncbi.nlm.nih.gov/pubmed/34905536 http://dx.doi.org/10.1371/journal.pgen.1009962

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