Atezolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and lif...

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Detalles Bibliográficos
Autores principales: Lambert, Nicolas, Dauby, Solène, Dive, Dominique, Sadzot, Bernard, Maquet, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714204/
https://www.ncbi.nlm.nih.gov/pubmed/34856110
http://dx.doi.org/10.3201/eid2801.204809
Descripción
Sumario:Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance.

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