Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths

We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2–associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity...

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Autores principales: Heinrich, Fabian, Schröder, Ann Sophie, Gerberding, Anna-Lina, Gerling, Moritz, Langenwalder, Felicia, Lange, Philine, Heinemann, Axel, Bibiza-Freiwald, Eric, Nörz, Dominik Sebastian, Aepfelbacher, Martin, Pfefferle, Susanne, Ondruschka, Benjamin, Lütgehetmann, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714232/
https://www.ncbi.nlm.nih.gov/pubmed/34726595
http://dx.doi.org/10.3201/eid2801.211749
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author Heinrich, Fabian
Schröder, Ann Sophie
Gerberding, Anna-Lina
Gerling, Moritz
Langenwalder, Felicia
Lange, Philine
Heinemann, Axel
Bibiza-Freiwald, Eric
Nörz, Dominik Sebastian
Aepfelbacher, Martin
Pfefferle, Susanne
Ondruschka, Benjamin
Lütgehetmann, Marc
author_facet Heinrich, Fabian
Schröder, Ann Sophie
Gerberding, Anna-Lina
Gerling, Moritz
Langenwalder, Felicia
Lange, Philine
Heinemann, Axel
Bibiza-Freiwald, Eric
Nörz, Dominik Sebastian
Aepfelbacher, Martin
Pfefferle, Susanne
Ondruschka, Benjamin
Lütgehetmann, Marc
author_sort Heinrich, Fabian
collection PubMed
description We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2–associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.
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spelling pubmed-87142322022-01-04 Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths Heinrich, Fabian Schröder, Ann Sophie Gerberding, Anna-Lina Gerling, Moritz Langenwalder, Felicia Lange, Philine Heinemann, Axel Bibiza-Freiwald, Eric Nörz, Dominik Sebastian Aepfelbacher, Martin Pfefferle, Susanne Ondruschka, Benjamin Lütgehetmann, Marc Emerg Infect Dis Research Letter We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2–associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment. Centers for Disease Control and Prevention 2022-01 /pmc/articles/PMC8714232/ /pubmed/34726595 http://dx.doi.org/10.3201/eid2801.211749 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Heinrich, Fabian
Schröder, Ann Sophie
Gerberding, Anna-Lina
Gerling, Moritz
Langenwalder, Felicia
Lange, Philine
Heinemann, Axel
Bibiza-Freiwald, Eric
Nörz, Dominik Sebastian
Aepfelbacher, Martin
Pfefferle, Susanne
Ondruschka, Benjamin
Lütgehetmann, Marc
Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title_full Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title_fullStr Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title_full_unstemmed Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title_short Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths
title_sort postmortem antigen-detecting rapid diagnostic tests to predict infectivity of sars-cov-2–associated deaths
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714232/
https://www.ncbi.nlm.nih.gov/pubmed/34726595
http://dx.doi.org/10.3201/eid2801.211749
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