In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of...

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Autores principales: Rümke, Lidewij W, Groenveld, Femke C, van Os, Yvonne M G, Praest, Patrique, Tanja, Anniek A N, de Jong, Dorien T C M, Symons, Jori, Schuurman, Rob, Reinders, Tessa, Hofstra, L Marije, Nierkens, Stefan, Thijsen, Steven F T, Heron, Michiel, Lebbink, Robert-Jan, Beekman, Jeffrey M, Nijhuis, Monique, Wensing, Annemarie M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714358/
https://www.ncbi.nlm.nih.gov/pubmed/34988250
http://dx.doi.org/10.1093/ofid/ofab553
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author Rümke, Lidewij W
Groenveld, Femke C
van Os, Yvonne M G
Praest, Patrique
Tanja, Anniek A N
de Jong, Dorien T C M
Symons, Jori
Schuurman, Rob
Reinders, Tessa
Hofstra, L Marije
Nierkens, Stefan
Thijsen, Steven F T
Heron, Michiel
Lebbink, Robert-Jan
Beekman, Jeffrey M
Nijhuis, Monique
Wensing, Annemarie M J
author_facet Rümke, Lidewij W
Groenveld, Femke C
van Os, Yvonne M G
Praest, Patrique
Tanja, Anniek A N
de Jong, Dorien T C M
Symons, Jori
Schuurman, Rob
Reinders, Tessa
Hofstra, L Marije
Nierkens, Stefan
Thijsen, Steven F T
Heron, Michiel
Lebbink, Robert-Jan
Beekman, Jeffrey M
Nijhuis, Monique
Wensing, Annemarie M J
author_sort Rümke, Lidewij W
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.
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spelling pubmed-87143582022-01-04 In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center Rümke, Lidewij W Groenveld, Femke C van Os, Yvonne M G Praest, Patrique Tanja, Anniek A N de Jong, Dorien T C M Symons, Jori Schuurman, Rob Reinders, Tessa Hofstra, L Marije Nierkens, Stefan Thijsen, Steven F T Heron, Michiel Lebbink, Robert-Jan Beekman, Jeffrey M Nijhuis, Monique Wensing, Annemarie M J Open Forum Infect Dis Brief Reports Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination. Oxford University Press 2021-11-06 /pmc/articles/PMC8714358/ /pubmed/34988250 http://dx.doi.org/10.1093/ofid/ofab553 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Rümke, Lidewij W
Groenveld, Femke C
van Os, Yvonne M G
Praest, Patrique
Tanja, Anniek A N
de Jong, Dorien T C M
Symons, Jori
Schuurman, Rob
Reinders, Tessa
Hofstra, L Marije
Nierkens, Stefan
Thijsen, Steven F T
Heron, Michiel
Lebbink, Robert-Jan
Beekman, Jeffrey M
Nijhuis, Monique
Wensing, Annemarie M J
In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title_full In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title_fullStr In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title_full_unstemmed In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title_short In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
title_sort in-depth characterization of vaccine breakthrough infections with sars-cov-2 among health care workers in a dutch academic medical center
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714358/
https://www.ncbi.nlm.nih.gov/pubmed/34988250
http://dx.doi.org/10.1093/ofid/ofab553
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