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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. The efficacy of...

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Detalles Bibliográficos
Autores principales: Jiang, Nan, Wu, Cheng, Zhou, Xunrong, Zhai, Guanghua, Wu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714392/
https://www.ncbi.nlm.nih.gov/pubmed/34970630
http://dx.doi.org/10.1155/2021/5353785
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author Jiang, Nan
Wu, Cheng
Zhou, Xunrong
Zhai, Guanghua
Wu, Jian
author_facet Jiang, Nan
Wu, Cheng
Zhou, Xunrong
Zhai, Guanghua
Wu, Jian
author_sort Jiang, Nan
collection PubMed
description Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. The efficacy of first- and second-line treatment options for ED is poor. A great deal of research has been devoted to exploring new methods of neuroprotection and nerve regeneration to save erectile function in patients with CNIED, especially in patients with cavernous nerve injury after prostate cancer surgery. In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. In the context of today's modern medicine, these new therapeutic techniques are expected to be new tools in the treatment of cavernous nerve injury erectile dysfunction. This article presents the main causes, mechanisms, and treatment of cavernous nerve injury erectile dysfunction and combines them with new treatment strategies.
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spelling pubmed-87143922021-12-29 Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration Jiang, Nan Wu, Cheng Zhou, Xunrong Zhai, Guanghua Wu, Jian J Immunol Res Review Article Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. The efficacy of first- and second-line treatment options for ED is poor. A great deal of research has been devoted to exploring new methods of neuroprotection and nerve regeneration to save erectile function in patients with CNIED, especially in patients with cavernous nerve injury after prostate cancer surgery. In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. In the context of today's modern medicine, these new therapeutic techniques are expected to be new tools in the treatment of cavernous nerve injury erectile dysfunction. This article presents the main causes, mechanisms, and treatment of cavernous nerve injury erectile dysfunction and combines them with new treatment strategies. Hindawi 2021-12-21 /pmc/articles/PMC8714392/ /pubmed/34970630 http://dx.doi.org/10.1155/2021/5353785 Text en Copyright © 2021 Nan Jiang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jiang, Nan
Wu, Cheng
Zhou, Xunrong
Zhai, Guanghua
Wu, Jian
Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title_full Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title_fullStr Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title_full_unstemmed Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title_short Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration
title_sort cavernous nerve injury resulted erectile dysfunction and regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714392/
https://www.ncbi.nlm.nih.gov/pubmed/34970630
http://dx.doi.org/10.1155/2021/5353785
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AT zhaiguanghua cavernousnerveinjuryresultederectiledysfunctionandregeneration
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