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Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity

BACKGROUND: It is well established that body mass index (BMI) and troponins are independently associated. However, whether the obesity could cause myocardial injury independent of coronary heart disease (CHD) remains unclear. This study focuses on the relationship between BMI and troponins, and whet...

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Autores principales: Huang, Jiaojiao, Liu, Ming, Su, Enyong, Yu, Peng, Jiang, Hong, Zhao, Ji, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714432/
https://www.ncbi.nlm.nih.gov/pubmed/34963447
http://dx.doi.org/10.1186/s12872-021-02445-0
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author Huang, Jiaojiao
Liu, Ming
Su, Enyong
Yu, Peng
Jiang, Hong
Zhao, Ji
Ge, Junbo
author_facet Huang, Jiaojiao
Liu, Ming
Su, Enyong
Yu, Peng
Jiang, Hong
Zhao, Ji
Ge, Junbo
author_sort Huang, Jiaojiao
collection PubMed
description BACKGROUND: It is well established that body mass index (BMI) and troponins are independently associated. However, whether the obesity could cause myocardial injury independent of coronary heart disease (CHD) remains unclear. This study focuses on the relationship between BMI and troponins, and whether this relationship is being attenuated when CHD is accounted for. METHODS: In populations without acute ischemic events, 383 patients with coronary artery stenosis less than 75% were included, that is, people who have not yet reached the indications for coronary intervention, and of them 70 patients being obese according to BMI ≥ 28 kg/m(2). Continuous variables were represented as mean ± SD or median(inter quartile range[IQR]). Chi-square test was adopted for categorical data. Correlations between variables were evaluated by Spearman analysis, multiple regression or logistic regression. RESULTS: The circulating hs-cTnT level was higher in the obese group [8(6,11) ng/L vs. 6(4,9) ng/L; p < 0.001). In subgroup analysis based on the presence or absence of coronary heart disease(CHD), the adjusted β(95%CI) for circulating hs-cTnT exhibited a proportional relationship with BMI when the non-obesity were defined as the reference[β; 2.22(95%CI, 0.73 to 3.71) in non-CHD, 5.58(95%CI, 0.70 to 10.46) in CHD, p < 0.05]. Additionally, the degree of coronary stenosis has shown a positive correlation with circulating hs-cTnT (rho = 0.1162; p < 0.05). CONCLUSION: When CHD is taken into account, obesity is independently associated to the elevation of circulating hs-cTnT, a biomarker of myocardial injury, potentially indicating the impact of obesity on non-ischemic subclinical myocardial injury.
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spelling pubmed-87144322022-01-05 Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity Huang, Jiaojiao Liu, Ming Su, Enyong Yu, Peng Jiang, Hong Zhao, Ji Ge, Junbo BMC Cardiovasc Disord Research BACKGROUND: It is well established that body mass index (BMI) and troponins are independently associated. However, whether the obesity could cause myocardial injury independent of coronary heart disease (CHD) remains unclear. This study focuses on the relationship between BMI and troponins, and whether this relationship is being attenuated when CHD is accounted for. METHODS: In populations without acute ischemic events, 383 patients with coronary artery stenosis less than 75% were included, that is, people who have not yet reached the indications for coronary intervention, and of them 70 patients being obese according to BMI ≥ 28 kg/m(2). Continuous variables were represented as mean ± SD or median(inter quartile range[IQR]). Chi-square test was adopted for categorical data. Correlations between variables were evaluated by Spearman analysis, multiple regression or logistic regression. RESULTS: The circulating hs-cTnT level was higher in the obese group [8(6,11) ng/L vs. 6(4,9) ng/L; p < 0.001). In subgroup analysis based on the presence or absence of coronary heart disease(CHD), the adjusted β(95%CI) for circulating hs-cTnT exhibited a proportional relationship with BMI when the non-obesity were defined as the reference[β; 2.22(95%CI, 0.73 to 3.71) in non-CHD, 5.58(95%CI, 0.70 to 10.46) in CHD, p < 0.05]. Additionally, the degree of coronary stenosis has shown a positive correlation with circulating hs-cTnT (rho = 0.1162; p < 0.05). CONCLUSION: When CHD is taken into account, obesity is independently associated to the elevation of circulating hs-cTnT, a biomarker of myocardial injury, potentially indicating the impact of obesity on non-ischemic subclinical myocardial injury. BioMed Central 2021-12-28 /pmc/articles/PMC8714432/ /pubmed/34963447 http://dx.doi.org/10.1186/s12872-021-02445-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Huang, Jiaojiao
Liu, Ming
Su, Enyong
Yu, Peng
Jiang, Hong
Zhao, Ji
Ge, Junbo
Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title_full Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title_fullStr Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title_full_unstemmed Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title_short Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
title_sort elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714432/
https://www.ncbi.nlm.nih.gov/pubmed/34963447
http://dx.doi.org/10.1186/s12872-021-02445-0
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