Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children

BACKGROUND AND AIM: We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. METHODS AND RESULTS: A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemo...

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Detalles Bibliográficos
Autores principales: Thakkar, Dhwanee, Tiwari, Aseem K, Pabbi, Swati, Kapoor, Rohit, Aggarwal, Geet, Rastogi, Neha, Yadav, Satya Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714533/
https://www.ncbi.nlm.nih.gov/pubmed/34245131
http://dx.doi.org/10.1002/cnr2.1408
Descripción
Sumario:BACKGROUND AND AIM: We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. METHODS AND RESULTS: A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemotherapy and peg‐GCSF (100 microgram/kg single dose). Mean age was 7.7 years (range 2–15 years).The mean time from peg‐GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed. CONCLUSION: It is feasible and safe to mobilize PBSC with peg‐GCSF in children with cancer.

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