Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children

BACKGROUND AND AIM: We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. METHODS AND RESULTS: A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemo...

Descripción completa

Detalles Bibliográficos
Autores principales: Thakkar, Dhwanee, Tiwari, Aseem K, Pabbi, Swati, Kapoor, Rohit, Aggarwal, Geet, Rastogi, Neha, Yadav, Satya Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714533/
https://www.ncbi.nlm.nih.gov/pubmed/34245131
http://dx.doi.org/10.1002/cnr2.1408
_version_ 1784623926306930688
author Thakkar, Dhwanee
Tiwari, Aseem K
Pabbi, Swati
Kapoor, Rohit
Aggarwal, Geet
Rastogi, Neha
Yadav, Satya Prakash
author_facet Thakkar, Dhwanee
Tiwari, Aseem K
Pabbi, Swati
Kapoor, Rohit
Aggarwal, Geet
Rastogi, Neha
Yadav, Satya Prakash
author_sort Thakkar, Dhwanee
collection PubMed
description BACKGROUND AND AIM: We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. METHODS AND RESULTS: A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemotherapy and peg‐GCSF (100 microgram/kg single dose). Mean age was 7.7 years (range 2–15 years).The mean time from peg‐GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed. CONCLUSION: It is feasible and safe to mobilize PBSC with peg‐GCSF in children with cancer.
format Online
Article
Text
id pubmed-8714533
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-87145332022-01-05 Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children Thakkar, Dhwanee Tiwari, Aseem K Pabbi, Swati Kapoor, Rohit Aggarwal, Geet Rastogi, Neha Yadav, Satya Prakash Cancer Rep (Hoboken) Brief Report BACKGROUND AND AIM: We report here our experience of using pegylated granulocyte colony stimulating factor (peg‐GCSF) for peripheral blood stem cell (PBSC) mobilization in children. METHODS AND RESULTS: A total of nine children suffering from high‐risk/relapsed solid tumors were mobilized with chemotherapy and peg‐GCSF (100 microgram/kg single dose). Mean age was 7.7 years (range 2–15 years).The mean time from peg‐GCSF administration to PBSC harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg) could be harvested in all children by a single apheresis procedure. No major adverse events observed. CONCLUSION: It is feasible and safe to mobilize PBSC with peg‐GCSF in children with cancer. John Wiley and Sons Inc. 2021-07-10 /pmc/articles/PMC8714533/ /pubmed/34245131 http://dx.doi.org/10.1002/cnr2.1408 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Thakkar, Dhwanee
Tiwari, Aseem K
Pabbi, Swati
Kapoor, Rohit
Aggarwal, Geet
Rastogi, Neha
Yadav, Satya Prakash
Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title_full Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title_fullStr Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title_full_unstemmed Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title_short Peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
title_sort peripheral blood stem cell mobilization with pegylated granulocyte colony stimulating factor in children
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714533/
https://www.ncbi.nlm.nih.gov/pubmed/34245131
http://dx.doi.org/10.1002/cnr2.1408
work_keys_str_mv AT thakkardhwanee peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT tiwariaseemk peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT pabbiswati peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT kapoorrohit peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT aggarwalgeet peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT rastogineha peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren
AT yadavsatyaprakash peripheralbloodstemcellmobilizationwithpegylatedgranulocytecolonystimulatingfactorinchildren

Ejemplares similares