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Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease

BACKGROUND: Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence. AIMS: Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of...

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Autores principales: Orjuela‐Grimm, Manuela, Carreño, Silvia Bhatt, Liu, Xinhua, Ruiz, Ambar, Medina, Paola, Ramirez Ortiz, Marco A., Rendon, Josefina Romero, Molina, Norma Citlali Lara, Pinilla, Hector, Hinojosa, Daniela, Rodriguez, Laura, Connor, Anita O', Rodriguez, Fabiola Mejia, Castañeda, M. Veronica Ponce, Cabrera‐Muñoz, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714544/
https://www.ncbi.nlm.nih.gov/pubmed/33960746
http://dx.doi.org/10.1002/cnr2.1409
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author Orjuela‐Grimm, Manuela
Carreño, Silvia Bhatt
Liu, Xinhua
Ruiz, Ambar
Medina, Paola
Ramirez Ortiz, Marco A.
Rendon, Josefina Romero
Molina, Norma Citlali Lara
Pinilla, Hector
Hinojosa, Daniela
Rodriguez, Laura
Connor, Anita O'
Rodriguez, Fabiola Mejia
Castañeda, M. Veronica Ponce
Cabrera‐Muñoz, Lourdes
author_facet Orjuela‐Grimm, Manuela
Carreño, Silvia Bhatt
Liu, Xinhua
Ruiz, Ambar
Medina, Paola
Ramirez Ortiz, Marco A.
Rendon, Josefina Romero
Molina, Norma Citlali Lara
Pinilla, Hector
Hinojosa, Daniela
Rodriguez, Laura
Connor, Anita O'
Rodriguez, Fabiola Mejia
Castañeda, M. Veronica Ponce
Cabrera‐Muñoz, Lourdes
author_sort Orjuela‐Grimm, Manuela
collection PubMed
description BACKGROUND: Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence. AIMS: Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma. METHODS AND RESULTS: We interviewed 511 mothers in the EpiRbMx case‐control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Weekly sun exposure was compared by age period, between unilateral (n = 259), bilateral (n = 120), and control (n = 132) children, accounting for two factors affecting UV exposure: residential elevation and reported use of coverings to shield eyes. For cases, association between sunlight exposure and clinical stage was examined by laterality at each age period. After adjusting for maternal education and elevation, sun exposure was lower in cases than controls in all three age periods especially during the first 6 months, and in children 12–23 months whose mothers did not cover their eyes when outdoors. In children diagnosed after 12 months of age, sun exposure during the second year of life (age 12–23 months) appeared inversely correlated (r = −0.25) with more advanced intraocular disease in bilateral Rtb children after adjusting for maternal education, residential elevation, and age of diagnosis (p < .09) consistent with effects of Vitamin D exposure on intraocular spread in earlier transgenic murine models of retinoblastoma, and suggesting potential chemopreventive strategies. CONCLUSION: Sun exposure in early childhood is protective for retinoblastoma and may decrease degree of intraocular spread in children with bilateral Rtb.
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spelling pubmed-87145442022-01-05 Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease Orjuela‐Grimm, Manuela Carreño, Silvia Bhatt Liu, Xinhua Ruiz, Ambar Medina, Paola Ramirez Ortiz, Marco A. Rendon, Josefina Romero Molina, Norma Citlali Lara Pinilla, Hector Hinojosa, Daniela Rodriguez, Laura Connor, Anita O' Rodriguez, Fabiola Mejia Castañeda, M. Veronica Ponce Cabrera‐Muñoz, Lourdes Cancer Rep (Hoboken) Original Article BACKGROUND: Prior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence. AIMS: Our study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma. METHODS AND RESULTS: We interviewed 511 mothers in the EpiRbMx case‐control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Weekly sun exposure was compared by age period, between unilateral (n = 259), bilateral (n = 120), and control (n = 132) children, accounting for two factors affecting UV exposure: residential elevation and reported use of coverings to shield eyes. For cases, association between sunlight exposure and clinical stage was examined by laterality at each age period. After adjusting for maternal education and elevation, sun exposure was lower in cases than controls in all three age periods especially during the first 6 months, and in children 12–23 months whose mothers did not cover their eyes when outdoors. In children diagnosed after 12 months of age, sun exposure during the second year of life (age 12–23 months) appeared inversely correlated (r = −0.25) with more advanced intraocular disease in bilateral Rtb children after adjusting for maternal education, residential elevation, and age of diagnosis (p < .09) consistent with effects of Vitamin D exposure on intraocular spread in earlier transgenic murine models of retinoblastoma, and suggesting potential chemopreventive strategies. CONCLUSION: Sun exposure in early childhood is protective for retinoblastoma and may decrease degree of intraocular spread in children with bilateral Rtb. John Wiley and Sons Inc. 2021-05-07 /pmc/articles/PMC8714544/ /pubmed/33960746 http://dx.doi.org/10.1002/cnr2.1409 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Orjuela‐Grimm, Manuela
Carreño, Silvia Bhatt
Liu, Xinhua
Ruiz, Ambar
Medina, Paola
Ramirez Ortiz, Marco A.
Rendon, Josefina Romero
Molina, Norma Citlali Lara
Pinilla, Hector
Hinojosa, Daniela
Rodriguez, Laura
Connor, Anita O'
Rodriguez, Fabiola Mejia
Castañeda, M. Veronica Ponce
Cabrera‐Muñoz, Lourdes
Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title_full Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title_fullStr Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title_full_unstemmed Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title_short Sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
title_sort sunlight exposure in infancy decreases risk of sporadic retinoblastoma, extent of intraocular disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714544/
https://www.ncbi.nlm.nih.gov/pubmed/33960746
http://dx.doi.org/10.1002/cnr2.1409
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