Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children

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In children lacking influenza-specific adaptive immunity, upper respiratory tract innate immune responses may influence viral replication and disease outcome. We use trivalent live attenuated influenza vaccine (LAIV) as a surrogate challenge model in children aged 24–59 months to identify pre-infect...

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Detalles Bibliográficos
Autores principales: Costa-Martins, André G., Mane, Karim, Lindsey, Benjamin B., Ogava, Rodrigo L.T., Castro, Ícaro, Jagne, Ya Jankey, Sallah, Hadijatou J., Armitage, Edwin P., Jarju, Sheikh, Ahadzie, Bankole, Ellis-Watson, Rebecca, Tregoning, John S., Bingle, Colin D., Bogaert, Debby, Clarke, Ed, Ordovas-Montanes, Jose, Jeffries, David, Kampmann, Beate, Nakaya, Helder I., de Silva, Thushan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714852/
https://www.ncbi.nlm.nih.gov/pubmed/35028607
http://dx.doi.org/10.1016/j.xcrm.2021.100465
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