Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. Third generation (3G) CARs extend this linear blueprint by fusing both co-stimulatory units in series. However, clinical impact has...

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Detalles Bibliográficos
Autores principales: Muliaditan, Tamara, Halim, Leena, Whilding, Lynsey M., Draper, Benjamin, Achkova, Daniela Y., Kausar, Fahima, Glover, Maya, Bechman, Natasha, Arulappu, Appitha, Sanchez, Jenifer, Flaherty, Katie R., Obajdin, Jana, Grigoriadis, Kristiana, Antoine, Pierre, Larcombe-Young, Daniel, Hull, Caroline M., Buus, Richard, Gordon, Peter, Grigoriadis, Anita, Davies, David M., Schurich, Anna, Maher, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714859/
https://www.ncbi.nlm.nih.gov/pubmed/35028604
http://dx.doi.org/10.1016/j.xcrm.2021.100457

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