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A Glimpse in the Future of Malignant Mesothelioma Treatment

Malignant mesothelioma (MMe) is a rare neoplasm with few therapeutic options available. The landscape of effective therapy for this disease remained unchanged in the last two decades. Recently, however, the introduction of Immune Checkpoint Inhibitors (ICIs) led to small, but nevertheless, promising...

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Autores principales: Pezzicoli, Gaetano, Rizzo, Mimma, Perrone, Martina, Minei, Silvia, Mutti, Luciano, Porta, Camillo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714955/
https://www.ncbi.nlm.nih.gov/pubmed/34975505
http://dx.doi.org/10.3389/fphar.2021.809337
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author Pezzicoli, Gaetano
Rizzo, Mimma
Perrone, Martina
Minei, Silvia
Mutti, Luciano
Porta, Camillo
author_facet Pezzicoli, Gaetano
Rizzo, Mimma
Perrone, Martina
Minei, Silvia
Mutti, Luciano
Porta, Camillo
author_sort Pezzicoli, Gaetano
collection PubMed
description Malignant mesothelioma (MMe) is a rare neoplasm with few therapeutic options available. The landscape of effective therapy for this disease remained unchanged in the last two decades. Recently, however, the introduction of Immune Checkpoint Inhibitors (ICIs) led to small, but nevertheless, promising improvements. However, many efforts are still needed to radically improve the prognosis of MMe. In this review, we analyze all those therapeutic strategies for MMe that are still in a preclinical or early clinical phase of development. In particular, we focus on novel antiangiogenic drugs and their possible combination with immunotherapy. Furthermore, we describe also more complex strategies such as microRNA-loaded vectors, oncolytic viruses, and engineered lymphocytes.
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spelling pubmed-87149552021-12-30 A Glimpse in the Future of Malignant Mesothelioma Treatment Pezzicoli, Gaetano Rizzo, Mimma Perrone, Martina Minei, Silvia Mutti, Luciano Porta, Camillo Front Pharmacol Pharmacology Malignant mesothelioma (MMe) is a rare neoplasm with few therapeutic options available. The landscape of effective therapy for this disease remained unchanged in the last two decades. Recently, however, the introduction of Immune Checkpoint Inhibitors (ICIs) led to small, but nevertheless, promising improvements. However, many efforts are still needed to radically improve the prognosis of MMe. In this review, we analyze all those therapeutic strategies for MMe that are still in a preclinical or early clinical phase of development. In particular, we focus on novel antiangiogenic drugs and their possible combination with immunotherapy. Furthermore, we describe also more complex strategies such as microRNA-loaded vectors, oncolytic viruses, and engineered lymphocytes. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8714955/ /pubmed/34975505 http://dx.doi.org/10.3389/fphar.2021.809337 Text en Copyright © 2021 Pezzicoli, Rizzo, Perrone, Minei, Mutti and Porta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Pezzicoli, Gaetano
Rizzo, Mimma
Perrone, Martina
Minei, Silvia
Mutti, Luciano
Porta, Camillo
A Glimpse in the Future of Malignant Mesothelioma Treatment
title A Glimpse in the Future of Malignant Mesothelioma Treatment
title_full A Glimpse in the Future of Malignant Mesothelioma Treatment
title_fullStr A Glimpse in the Future of Malignant Mesothelioma Treatment
title_full_unstemmed A Glimpse in the Future of Malignant Mesothelioma Treatment
title_short A Glimpse in the Future of Malignant Mesothelioma Treatment
title_sort glimpse in the future of malignant mesothelioma treatment
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714955/
https://www.ncbi.nlm.nih.gov/pubmed/34975505
http://dx.doi.org/10.3389/fphar.2021.809337
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