Cargando…

Involvement of P-gp on Reversing Multidrug Resistance Effects of 23-Hydroxybetulinic Acid on Chemotherapeutic Agents

Betulinic acid (BA) and 23-Hydroxybetulinic acid (23-HBA) are natural products with similar structures, which show a range of biological effects including cytotoxicity activity. The aim of current research was to investigate and evaluate the combinational cytotoxicity of BA and 23-HBA with chemother...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhihao, Wen, Xiaozhou, Wang, Guangji, Zhou, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714961/ https://www.ncbi.nlm.nih.gov/pubmed/34975494 http://dx.doi.org/10.3389/fphar.2021.796745

Ejemplares similares

Identification of cytochrome P450 isoenzymes involved in the metabolism of 23-hydroxybetulinic acid in human liver microsomes
por: Zhou, Ying, et al.
Publicado: (2019)

Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
por: Bi, Yi, et al.
Publicado: (2012)

Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells
por: Zhang, Lei, et al.
Publicado: (2022)

CD44-targeted hyaluronic acid–curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways
por: Diao, Lu, et al.
Publicado: (2019)

Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance
por: Luo, Xiaofang, et al.
Publicado: (2020)

Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents
por: Bai, Bingke, et al.
Publicado: (2021)

Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp
por: Laiolo, Jerónimo, et al.
Publicado: (2021)

Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5
por: Sachs, Julia, et al.
Publicado: (2019)

Brucea javanica oil alleviates intestinal mucosal injury induced by chemotherapeutic agent 5-fluorouracil in mice
por: Zheng, Xinghan, et al.
Publicado: (2023)

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study
por: Feng, Sen-Ling, et al.
Publicado: (2020)

Nanodrug delivery in reversing multidrug resistance in cancer cells
por: Kapse-Mistry, Sonali, et al.
Publicado: (2014)

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
por: Deng, Zhuo-fen, et al.
Publicado: (2022)

A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells
por: Wang, Liang, et al.
Publicado: (2016)

Combinatorial regimens of chemotherapeutic agents: A new perspective on raising the heat of the tumor immune microenvironment
por: Liu, Jingyang, et al.
Publicado: (2022)

Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo
por: Wang, Gangyang, et al.
Publicado: (2022)

Therapeutic Potential and Molecular Mechanisms of Emblica officinalis Gaertn in Countering Nephrotoxicity in Rats Induced by the Chemotherapeutic Agent Cisplatin
por: Malik, Salma, et al.
Publicado: (2016)

Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp
por: Zhang, Xulong, et al.
Publicado: (2011)

Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?
por: Conde, João, et al.
Publicado: (2013)

Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects
por: Aggarwal, Nikita, et al.
Publicado: (2021)

Chemotherapeutic drugs for soft tissue sarcomas: a review
por: Tian, Zhichao, et al.
Publicado: (2023)

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
por: Dahlgren, David, et al.
Publicado: (2021)

Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update
por: Naik, Rajashri R., et al.
Publicado: (2023)

CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? −inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration
por: OGUSHI, Naofumi, et al.
Publicado: (2016)

A Rare Class of New Dimeric Naphthoquinones from Diospyros lotus have Multidrug Reversal and Antiproliferative Effects
por: Rauf, Abdur, et al.
Publicado: (2015)

MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitro
por: Xie, Yangmei, et al.
Publicado: (2018)

Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway
por: Jiang, Lu, et al.
Publicado: (2021)

Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
por: Wu, Shaocong, et al.
Publicado: (2018)

Is There an Opportunity for Current Chemotherapeutics to Up-regulate MIC-A/B Ligands?
por: Quirk, Kendel, et al.
Publicado: (2017)

Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
por: Gong, Xianling, et al.
Publicado: (2018)

Evaluation of Chemotherapeutic Agents
por: Engstrom, W. W.
Publicado: (1949)

Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells
por: Elbezanti, Weam Othman, et al.
Publicado: (2022)

Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy
por: Xu, Jin-Feng, et al.
Publicado: (2021)

Frog intestinal perfusion to evaluate drug permeability: application to p-gp and cyp3a4 substrates
por: Yerasi, Neelima, et al.
Publicado: (2015)

Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1
por: Pu, Jing, et al.
Publicado: (2021)

Involvement of CUL4A in Regulation of Multidrug Resistance to P-gp Substrate Drugs in Breast Cancer Cells
por: Wang, Yunshan, et al.
Publicado: (2013)

Corrigendum: Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
por: Gong, Xianling, et al.
Publicado: (2021)

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †
por: Teodori, Elisabetta, et al.
Publicado: (2020)

Mechanisms of resistance to chemotherapeutic and anti-angiogenic drugs as novel targets for pancreatic cancer therapy
por: Tamburrino, Anna, et al.
Publicado: (2013)

Suppression of CD13 Enhances the Cytotoxic Effect of Chemotherapeutic Drugs in Hepatocellular Carcinoma Cells
por: Ji, Shengping, et al.
Publicado: (2021)

Natural Bioactive Molecules as Potential Agents Against SARS-CoV-2
por: Chen, Wei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ghmvkighr0j29ahfqj3qitujaa