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Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still u...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715005/ https://www.ncbi.nlm.nih.gov/pubmed/34975504 http://dx.doi.org/10.3389/fphar.2021.808144 |
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author | Qian, Kai Fu, Dan Jiang, Baorui Wang, Yue Tian, Fei Song, Li Li, Lei |
author_facet | Qian, Kai Fu, Dan Jiang, Baorui Wang, Yue Tian, Fei Song, Li Li, Lei |
author_sort | Qian, Kai |
collection | PubMed |
description | Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application. |
format | Online Article Text |
id | pubmed-8715005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87150052021-12-30 Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer Qian, Kai Fu, Dan Jiang, Baorui Wang, Yue Tian, Fei Song, Li Li, Lei Front Pharmacol Pharmacology Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8715005/ /pubmed/34975504 http://dx.doi.org/10.3389/fphar.2021.808144 Text en Copyright © 2021 Qian, Fu, Jiang, Wang, Tian, Song and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Qian, Kai Fu, Dan Jiang, Baorui Wang, Yue Tian, Fei Song, Li Li, Lei Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title | Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title_full | Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title_fullStr | Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title_full_unstemmed | Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title_short | Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer |
title_sort | mechanism of hedyotis diffusa in the treatment of cervical cancer |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715005/ https://www.ncbi.nlm.nih.gov/pubmed/34975504 http://dx.doi.org/10.3389/fphar.2021.808144 |
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