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Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer

Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still u...

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Autores principales: Qian, Kai, Fu, Dan, Jiang, Baorui, Wang, Yue, Tian, Fei, Song, Li, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715005/
https://www.ncbi.nlm.nih.gov/pubmed/34975504
http://dx.doi.org/10.3389/fphar.2021.808144
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author Qian, Kai
Fu, Dan
Jiang, Baorui
Wang, Yue
Tian, Fei
Song, Li
Li, Lei
author_facet Qian, Kai
Fu, Dan
Jiang, Baorui
Wang, Yue
Tian, Fei
Song, Li
Li, Lei
author_sort Qian, Kai
collection PubMed
description Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application.
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spelling pubmed-87150052021-12-30 Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer Qian, Kai Fu, Dan Jiang, Baorui Wang, Yue Tian, Fei Song, Li Li, Lei Front Pharmacol Pharmacology Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8715005/ /pubmed/34975504 http://dx.doi.org/10.3389/fphar.2021.808144 Text en Copyright © 2021 Qian, Fu, Jiang, Wang, Tian, Song and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Qian, Kai
Fu, Dan
Jiang, Baorui
Wang, Yue
Tian, Fei
Song, Li
Li, Lei
Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title_full Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title_fullStr Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title_full_unstemmed Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title_short Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer
title_sort mechanism of hedyotis diffusa in the treatment of cervical cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715005/
https://www.ncbi.nlm.nih.gov/pubmed/34975504
http://dx.doi.org/10.3389/fphar.2021.808144
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