Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses

In a recent issue of Cell Host and Microbe, Fiege and colleagues(1) report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses.

Detalles Bibliográficos
Autor principal: Coughlan, Lynda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715072/
https://www.ncbi.nlm.nih.gov/pubmed/35028623
http://dx.doi.org/10.1016/j.xcrm.2021.100484
Descripción
Sumario:In a recent issue of Cell Host and Microbe, Fiege and colleagues(1) report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses.

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