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Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy

OBJECTIVE: To review the current state of radiation therapy for uveal melanoma and compare particle radiation and brachytherapy. PATIENTS AND METHODS: The medical records of 156 patients treated for uveal melanoma between May 30, 2012, and March 16, 2020, were retrospectively reviewed. Treatments co...

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Autores principales: Bolling, James P., Dagan, Roi, Rutenberg, Michael, Mamalui-Hunter, Maria, Buskirk, Steven J., Heckman, Michael G., Hochwald, Alexander P., Slopsema, Roelf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715138/
https://www.ncbi.nlm.nih.gov/pubmed/35005435
http://dx.doi.org/10.1016/j.mayocpiqo.2021.10.002
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author Bolling, James P.
Dagan, Roi
Rutenberg, Michael
Mamalui-Hunter, Maria
Buskirk, Steven J.
Heckman, Michael G.
Hochwald, Alexander P.
Slopsema, Roelf
author_facet Bolling, James P.
Dagan, Roi
Rutenberg, Michael
Mamalui-Hunter, Maria
Buskirk, Steven J.
Heckman, Michael G.
Hochwald, Alexander P.
Slopsema, Roelf
author_sort Bolling, James P.
collection PubMed
description OBJECTIVE: To review the current state of radiation therapy for uveal melanoma and compare particle radiation and brachytherapy. PATIENTS AND METHODS: The medical records of 156 patients treated for uveal melanoma between May 30, 2012, and March 16, 2020, were retrospectively reviewed. Treatments consisted of either radioactive iodine 125 implant (RAI) or fractionated proton radiation (proton beam therapy [PBT]). Baseline characteristics were compared using a Wilcoxon rank sum test or χ(2) test. Outcomes were compared using Cox proportional hazards regression models or logistic regression models. RESULTS: The median length of follow-up after treatment was 2.7 years (range, 0.5 to 9.0 years). Patients who underwent treatment with RAI were older (median age, 67 vs 59 years; P<.001) and had a lower tumor classification (American Joint Commission on Cancer; P=.001) compared with those who underwent PBT. There was no significant difference between RAI and PBT in the outcomes of liver metastases, death, enucleation, tearing, vision loss, retinal detachment, tumor thickness, conjunctivitis, optic neuropathy, iris neovascularization, or neovascular glaucoma (all P>.05). Patients who underwent RAI treatment had significantly higher risk of diplopia (P<.001), cataract progression (P<.001), and maculopathy (P=.03) compared with those who received PBT. Patients who underwent RAI were at higher risk of eyelash loss (P=.006) compared with the PBT group. CONCLUSION: Treatment with PBT and RAI has similar efficacy; however, there are differences in the adverse outcomes associated with these 2 modalities.
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spelling pubmed-87151382022-01-06 Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy Bolling, James P. Dagan, Roi Rutenberg, Michael Mamalui-Hunter, Maria Buskirk, Steven J. Heckman, Michael G. Hochwald, Alexander P. Slopsema, Roelf Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: To review the current state of radiation therapy for uveal melanoma and compare particle radiation and brachytherapy. PATIENTS AND METHODS: The medical records of 156 patients treated for uveal melanoma between May 30, 2012, and March 16, 2020, were retrospectively reviewed. Treatments consisted of either radioactive iodine 125 implant (RAI) or fractionated proton radiation (proton beam therapy [PBT]). Baseline characteristics were compared using a Wilcoxon rank sum test or χ(2) test. Outcomes were compared using Cox proportional hazards regression models or logistic regression models. RESULTS: The median length of follow-up after treatment was 2.7 years (range, 0.5 to 9.0 years). Patients who underwent treatment with RAI were older (median age, 67 vs 59 years; P<.001) and had a lower tumor classification (American Joint Commission on Cancer; P=.001) compared with those who underwent PBT. There was no significant difference between RAI and PBT in the outcomes of liver metastases, death, enucleation, tearing, vision loss, retinal detachment, tumor thickness, conjunctivitis, optic neuropathy, iris neovascularization, or neovascular glaucoma (all P>.05). Patients who underwent RAI treatment had significantly higher risk of diplopia (P<.001), cataract progression (P<.001), and maculopathy (P=.03) compared with those who received PBT. Patients who underwent RAI were at higher risk of eyelash loss (P=.006) compared with the PBT group. CONCLUSION: Treatment with PBT and RAI has similar efficacy; however, there are differences in the adverse outcomes associated with these 2 modalities. Elsevier 2021-12-22 /pmc/articles/PMC8715138/ /pubmed/35005435 http://dx.doi.org/10.1016/j.mayocpiqo.2021.10.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Bolling, James P.
Dagan, Roi
Rutenberg, Michael
Mamalui-Hunter, Maria
Buskirk, Steven J.
Heckman, Michael G.
Hochwald, Alexander P.
Slopsema, Roelf
Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title_full Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title_fullStr Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title_full_unstemmed Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title_short Treatment of Uveal Melanoma With Radioactive Iodine 125 Implant Compared With Proton Beam Radiotherapy
title_sort treatment of uveal melanoma with radioactive iodine 125 implant compared with proton beam radiotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715138/
https://www.ncbi.nlm.nih.gov/pubmed/35005435
http://dx.doi.org/10.1016/j.mayocpiqo.2021.10.002
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