Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice

Deep brain stimulation (DBS) entails neurosurgery to implant electrodes in specific brain structures to modulate the behavior of a particular neural circuit. DBS is best known for treating advanced Parkinson disease and can potentially be applicable to other motor and even cognitive dysfunctions. He...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Tang, Bin, Tang, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715214/
https://www.ncbi.nlm.nih.gov/pubmed/35005636
http://dx.doi.org/10.1016/j.xpro.2021.101054
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author Wang, Qi
Tang, Bin
Tang, Jianrong
author_facet Wang, Qi
Tang, Bin
Tang, Jianrong
author_sort Wang, Qi
collection PubMed
description Deep brain stimulation (DBS) entails neurosurgery to implant electrodes in specific brain structures to modulate the behavior of a particular neural circuit. DBS is best known for treating advanced Parkinson disease and can potentially be applicable to other motor and even cognitive dysfunctions. Here, we describe a detailed protocol allowing for electrode preparation, surgical procedures, stimulation delivery, and field potential recordings in both anesthetized and behaving mice, and the benefit evaluation of DBS at the fimbria-fornix by using a fear conditioning test. For complete details on the use and execution of this protocol, please refer to Hao et al. (2015).
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spelling pubmed-87152142022-01-06 Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice Wang, Qi Tang, Bin Tang, Jianrong STAR Protoc Protocol Deep brain stimulation (DBS) entails neurosurgery to implant electrodes in specific brain structures to modulate the behavior of a particular neural circuit. DBS is best known for treating advanced Parkinson disease and can potentially be applicable to other motor and even cognitive dysfunctions. Here, we describe a detailed protocol allowing for electrode preparation, surgical procedures, stimulation delivery, and field potential recordings in both anesthetized and behaving mice, and the benefit evaluation of DBS at the fimbria-fornix by using a fear conditioning test. For complete details on the use and execution of this protocol, please refer to Hao et al. (2015). Elsevier 2021-12-21 /pmc/articles/PMC8715214/ /pubmed/35005636 http://dx.doi.org/10.1016/j.xpro.2021.101054 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Wang, Qi
Tang, Bin
Tang, Jianrong
Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title_full Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title_fullStr Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title_full_unstemmed Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title_short Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
title_sort protocol for deep brain stimulation in the fimbria-fornix of freely moving mice
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715214/
https://www.ncbi.nlm.nih.gov/pubmed/35005636
http://dx.doi.org/10.1016/j.xpro.2021.101054
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