Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine

OBJECTIVES: Anti‐CD20 monoclonal antibody therapy rapidly depletes > 95% of CD20(+) B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity...

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Detalles Bibliográficos
Autores principales: Ercoli, Giuseppe, Ramos‐Sevillano, Elisa, Pearce, Emma, Ragab, Sara, Goldblatt, David, Weckbecker, Gisbert, Brown, Jeremy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715227/
https://www.ncbi.nlm.nih.gov/pubmed/35003749
http://dx.doi.org/10.1002/cti2.1366

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