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Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Ionizable residues can release and take up protons and this has an influence on protein structure and function. The extent of protonation is linked to the overall pH of the solution and the local environments of ionizable residues. Binding or unbinding of a single proton generates a distinct charge...

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Detalles Bibliográficos
Autores principales: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715249/
https://www.ncbi.nlm.nih.gov/pubmed/34826385
http://dx.doi.org/10.1016/j.bpj.2021.11.2886

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