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Quantifying charge state heterogeneity for proteins with multiple ionizable residues
Ionizable residues can release and take up protons and this has an influence on protein structure and function. The extent of protonation is linked to the overall pH of the solution and the local environments of ionizable residues. Binding or unbinding of a single proton generates a distinct charge...
Autores principales: | Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715249/ https://www.ncbi.nlm.nih.gov/pubmed/34826385 http://dx.doi.org/10.1016/j.bpj.2021.11.2886 |
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