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Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation
[Image: see text] The efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack of a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications for the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715545/ https://www.ncbi.nlm.nih.gov/pubmed/34977901 http://dx.doi.org/10.1021/jacsau.1c00422 |
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author | Jana, Deblin Wang, Dongdong Rajendran, Praveenbalaji Bindra, Anivind Kaur Guo, Yi Liu, Jiawei Pramanik, Manojit Zhao, Yanli |
author_facet | Jana, Deblin Wang, Dongdong Rajendran, Praveenbalaji Bindra, Anivind Kaur Guo, Yi Liu, Jiawei Pramanik, Manojit Zhao, Yanli |
author_sort | Jana, Deblin |
collection | PubMed |
description | [Image: see text] The efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack of a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications for their biocompatibility and intrinsic fluorescence imaging capabilities, making them suitable for ROS generation. Herein, we synthesized a CD-based ultrasmall hybrid nanostructure possessing active sites of Mo, Cu, and IR-780 dye. After cooperative self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol), the obtained assembly (CMIR-CDa) exhibits near-infrared fluorescence imaging and photoacoustic tomography. Interestingly, CMIR-CDa can generate singlet oxygen ((1)O(2)), hydroxyl radical (·OH), and superoxide radical anion (O(2)(• –)) upon ultrasound stimulus owing to its sonosensitizing and enzyme-mimicking properties, showing an enhanced efficacy for tumor ablation in vivo. The collective in vitro and in vivo results indicate that CMIR-CDa has a high potency as an ROS nanogenerator under US irradiation, even at a low concentration. The present study offers an approach for engineering hybrid CDs in a bioinspired way for intratumoral ROS augmentation in response to deep tissue penetrable external stimuli. |
format | Online Article Text |
id | pubmed-8715545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87155452021-12-30 Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation Jana, Deblin Wang, Dongdong Rajendran, Praveenbalaji Bindra, Anivind Kaur Guo, Yi Liu, Jiawei Pramanik, Manojit Zhao, Yanli JACS Au [Image: see text] The efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack of a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications for their biocompatibility and intrinsic fluorescence imaging capabilities, making them suitable for ROS generation. Herein, we synthesized a CD-based ultrasmall hybrid nanostructure possessing active sites of Mo, Cu, and IR-780 dye. After cooperative self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol), the obtained assembly (CMIR-CDa) exhibits near-infrared fluorescence imaging and photoacoustic tomography. Interestingly, CMIR-CDa can generate singlet oxygen ((1)O(2)), hydroxyl radical (·OH), and superoxide radical anion (O(2)(• –)) upon ultrasound stimulus owing to its sonosensitizing and enzyme-mimicking properties, showing an enhanced efficacy for tumor ablation in vivo. The collective in vitro and in vivo results indicate that CMIR-CDa has a high potency as an ROS nanogenerator under US irradiation, even at a low concentration. The present study offers an approach for engineering hybrid CDs in a bioinspired way for intratumoral ROS augmentation in response to deep tissue penetrable external stimuli. American Chemical Society 2021-11-13 /pmc/articles/PMC8715545/ /pubmed/34977901 http://dx.doi.org/10.1021/jacsau.1c00422 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Jana, Deblin Wang, Dongdong Rajendran, Praveenbalaji Bindra, Anivind Kaur Guo, Yi Liu, Jiawei Pramanik, Manojit Zhao, Yanli Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title | Hybrid Carbon Dot Assembly as a Reactive Oxygen Species
Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title_full | Hybrid Carbon Dot Assembly as a Reactive Oxygen Species
Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title_fullStr | Hybrid Carbon Dot Assembly as a Reactive Oxygen Species
Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title_full_unstemmed | Hybrid Carbon Dot Assembly as a Reactive Oxygen Species
Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title_short | Hybrid Carbon Dot Assembly as a Reactive Oxygen Species
Nanogenerator for Ultrasound-Assisted Tumor Ablation |
title_sort | hybrid carbon dot assembly as a reactive oxygen species
nanogenerator for ultrasound-assisted tumor ablation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715545/ https://www.ncbi.nlm.nih.gov/pubmed/34977901 http://dx.doi.org/10.1021/jacsau.1c00422 |
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