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Selinexor in combination with standard chemotherapy in patients with advanced or metastatic solid tumors

Selinexor, an oral selective inhibitor of nuclear export (SINE), was demonstrated to hinder the DNA damage repair (DDR) system by reducing DDR proteins while enhancing the killing of cancer cells by DDR-based therapeutics in vivo studies. In this single-center, multi-arm phase 1b study, selinexor wi...

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Detalles Bibliográficos
Autores principales:	Thein, Kyaw Z., Piha-Paul, Sarina A., Tsimberidou, Apostolia, Karp, Daniel D., Janku, Filip, Fu, Siqing, Subbiah, Vivek, Hong, David S., Yap, Timothy A., Shah, Jatin, Milton, Denái R., McQuinn, Lacey, Gong, Jing, Tran, Yanyan, Carter, Brett W., Colen, Rivka, Meric-Bernstam, Funda, Naing, Aung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715578/ https://www.ncbi.nlm.nih.gov/pubmed/34965890 http://dx.doi.org/10.1186/s40164-021-00251-0

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