Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The...

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Detalles Bibliográficos
Autores principales: Legrand, Elena, Basu, Niladri, Hecker, Markus, Crump, Doug, Xia, Jianguo, Chandramouli, Bharat, Butler, Heather, Head, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715744/
https://www.ncbi.nlm.nih.gov/pubmed/34940609
http://dx.doi.org/10.3390/metabo11120850
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author Legrand, Elena
Basu, Niladri
Hecker, Markus
Crump, Doug
Xia, Jianguo
Chandramouli, Bharat
Butler, Heather
Head, Jessica A.
author_facet Legrand, Elena
Basu, Niladri
Hecker, Markus
Crump, Doug
Xia, Jianguo
Chandramouli, Bharat
Butler, Heather
Head, Jessica A.
author_sort Legrand, Elena
collection PubMed
description This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
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spelling pubmed-87157442021-12-30 Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages Legrand, Elena Basu, Niladri Hecker, Markus Crump, Doug Xia, Jianguo Chandramouli, Bharat Butler, Heather Head, Jessica A. Metabolites Communication This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies. MDPI 2021-12-08 /pmc/articles/PMC8715744/ /pubmed/34940609 http://dx.doi.org/10.3390/metabo11120850 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Legrand, Elena
Basu, Niladri
Hecker, Markus
Crump, Doug
Xia, Jianguo
Chandramouli, Bharat
Butler, Heather
Head, Jessica A.
Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title_full Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title_fullStr Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title_full_unstemmed Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title_short Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages
title_sort targeted metabolomics to assess exposure to environmental chemicals of concern in japanese quail at two life stages
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715744/
https://www.ncbi.nlm.nih.gov/pubmed/34940609
http://dx.doi.org/10.3390/metabo11120850
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