Cargando…
Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery
The definition of consciousness has been the subject of great interest for many scientists and philosophers. To better understand how evoked potentials may be identified as biomarkers of consciousness and recovery, the different theoretical models sustaining neural correlates of consciousness are re...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of Clinical Neurophysiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715993/ https://www.ncbi.nlm.nih.gov/pubmed/34474424 http://dx.doi.org/10.1097/WNP.0000000000000762 |
_version_ | 1784624229624315904 |
---|---|
author | Pruvost-Robieux, Estelle Marchi, Angela Martinelli, Ilaria Bouchereau, Eléonore Gavaret, Martine |
author_facet | Pruvost-Robieux, Estelle Marchi, Angela Martinelli, Ilaria Bouchereau, Eléonore Gavaret, Martine |
author_sort | Pruvost-Robieux, Estelle |
collection | PubMed |
description | The definition of consciousness has been the subject of great interest for many scientists and philosophers. To better understand how evoked potentials may be identified as biomarkers of consciousness and recovery, the different theoretical models sustaining neural correlates of consciousness are reviewed. A multimodal approach can help to better predict clinical outcome in patients presenting with disorders of consciousness. Evoked potentials are inexpensive and easy-to-implement bedside examination techniques. Evoked potentials are an integral part of prognostic evaluation, particularly in cases of cognitive motor dissociation. Prognostic criteria are well established in postanoxic disorders of consciousness, especially postcardiac arrest but are less well determined in other etiologies. In the early examination, bilateral absence of N20 in disorder of consciousness patients is strongly associated with unfavorable outcome (i.e., death or unresponsive wakefulness syndrome) especially in postanoxic etiologies. This predictive value is lower in other etiologies and probably also in children. Both N20 and mismatch negativity are proven outcome predictors for acute coma. Many studies have shown that mismatch negativity and P3a are characterized by a high prognostic value for awakening, but some patients presenting unresponsive wakefulness syndrome also process a P3a. The presence of long-latency event-related potential components in response to stimuli is indicative of a better recovery. All neurophysiological data must be integrated within a multimodal approach combining repeated clinical evaluation, neuroimaging, functional imaging, biology, and neurophysiology combining passive and active paradigms. |
format | Online Article Text |
id | pubmed-8715993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Journal of Clinical Neurophysiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-87159932022-01-03 Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery Pruvost-Robieux, Estelle Marchi, Angela Martinelli, Ilaria Bouchereau, Eléonore Gavaret, Martine J Clin Neurophysiol Invited Review The definition of consciousness has been the subject of great interest for many scientists and philosophers. To better understand how evoked potentials may be identified as biomarkers of consciousness and recovery, the different theoretical models sustaining neural correlates of consciousness are reviewed. A multimodal approach can help to better predict clinical outcome in patients presenting with disorders of consciousness. Evoked potentials are inexpensive and easy-to-implement bedside examination techniques. Evoked potentials are an integral part of prognostic evaluation, particularly in cases of cognitive motor dissociation. Prognostic criteria are well established in postanoxic disorders of consciousness, especially postcardiac arrest but are less well determined in other etiologies. In the early examination, bilateral absence of N20 in disorder of consciousness patients is strongly associated with unfavorable outcome (i.e., death or unresponsive wakefulness syndrome) especially in postanoxic etiologies. This predictive value is lower in other etiologies and probably also in children. Both N20 and mismatch negativity are proven outcome predictors for acute coma. Many studies have shown that mismatch negativity and P3a are characterized by a high prognostic value for awakening, but some patients presenting unresponsive wakefulness syndrome also process a P3a. The presence of long-latency event-related potential components in response to stimuli is indicative of a better recovery. All neurophysiological data must be integrated within a multimodal approach combining repeated clinical evaluation, neuroimaging, functional imaging, biology, and neurophysiology combining passive and active paradigms. Journal of Clinical Neurophysiology 2022-01 2021-08-27 /pmc/articles/PMC8715993/ /pubmed/34474424 http://dx.doi.org/10.1097/WNP.0000000000000762 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Clinical Neurophysiology Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Invited Review Pruvost-Robieux, Estelle Marchi, Angela Martinelli, Ilaria Bouchereau, Eléonore Gavaret, Martine Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title | Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title_full | Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title_fullStr | Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title_full_unstemmed | Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title_short | Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery |
title_sort | evoked and event-related potentials as biomarkers of consciousness state and recovery |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715993/ https://www.ncbi.nlm.nih.gov/pubmed/34474424 http://dx.doi.org/10.1097/WNP.0000000000000762 |
work_keys_str_mv | AT pruvostrobieuxestelle evokedandeventrelatedpotentialsasbiomarkersofconsciousnessstateandrecovery AT marchiangela evokedandeventrelatedpotentialsasbiomarkersofconsciousnessstateandrecovery AT martinelliilaria evokedandeventrelatedpotentialsasbiomarkersofconsciousnessstateandrecovery AT bouchereaueleonore evokedandeventrelatedpotentialsasbiomarkersofconsciousnessstateandrecovery AT gavaretmartine evokedandeventrelatedpotentialsasbiomarkersofconsciousnessstateandrecovery |