Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating

This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline. METHODS: Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bl...

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Detalles Bibliográficos
Autores principales: Staller, Kyle, Hinson, Jimmy, Kerstens, René, Spalding, William, Lembo, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715996/
https://www.ncbi.nlm.nih.gov/pubmed/34585675
http://dx.doi.org/10.14309/ajg.0000000000001521
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author Staller, Kyle
Hinson, Jimmy
Kerstens, René
Spalding, William
Lembo, Anthony
author_facet Staller, Kyle
Hinson, Jimmy
Kerstens, René
Spalding, William
Lembo, Anthony
author_sort Staller, Kyle
collection PubMed
description This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline. METHODS: Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0–4). RESULTS: The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%). DISCUSSION: The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population.
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spelling pubmed-87159962022-01-03 Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating Staller, Kyle Hinson, Jimmy Kerstens, René Spalding, William Lembo, Anthony Am J Gastroenterol Brief Communication This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline. METHODS: Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0–4). RESULTS: The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%). DISCUSSION: The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population. Wolters Kluwer 2022-01 2021-09-29 /pmc/articles/PMC8715996/ /pubmed/34585675 http://dx.doi.org/10.14309/ajg.0000000000001521 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Staller, Kyle
Hinson, Jimmy
Kerstens, René
Spalding, William
Lembo, Anthony
Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title_full Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title_fullStr Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title_full_unstemmed Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title_short Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
title_sort efficacy of prucalopride for chronic idiopathic constipation: an analysis of participants with moderate to very severe abdominal bloating
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715996/
https://www.ncbi.nlm.nih.gov/pubmed/34585675
http://dx.doi.org/10.14309/ajg.0000000000001521
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